PTGS1

Entrez Summary: This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. COMPLETENESS: complete on the 3' end.
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BRD2 inhibitor II 20μM R07 exp341	1.72
Palbociclib 1μM R07 exp382	2.11

prostaglandin-endoperoxide synthase activity
cyclooxygenase pathway
prostaglandin biosynthetic process
prostanoid biosynthetic process
dioxygenase activity
peroxidase activity
prostaglandin metabolic process
prostanoid metabolic process
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
arachidonic acid metabolic process
photoreceptor outer segment
cellular oxidant detoxification
fatty acid derivative biosynthetic process
cellular detoxification
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
detoxification
xenobiotic metabolic process
heme binding
fatty acid derivative metabolic process
regulation of blood pressure
monocarboxylic acid biosynthetic process
cellular response to xenobiotic stimulus
cellular response to toxic substance
response to xenobiotic stimulus
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
response to oxidative stress
blood circulation
circulatory system process
inflammatory response
response to toxic substance
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
intracellular membrane-bounded organelle