ATP4B

Entrez Summary: N/A
UniProt Summary: Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. {ECO:0000269|PubMed:19694409}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BN82002 4μM R07 exp340	1.71
Epigallocatechin gallate 20μM R05 exp230	1.71
Palbociclib 1μM R07 exp382	2.07

potassium:proton exchanging ATPase activity
sodium:potassium-exchanging ATPase activity
sodium:potassium-exchanging ATPase complex
cellular potassium ion homeostasis
sodium ion export across plasma membrane
establishment or maintenance of transmembrane electrochemical gradient
cellular sodium ion homeostasis
ATPase activator activity
potassium ion homeostasis
sodium ion homeostasis
export across plasma membrane
potassium ion import across plasma membrane
positive regulation of ATPase activity
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
regulation of ATPase activity
sodium ion transmembrane transport
import across plasma membrane
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
proton transmembrane transport
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
response to lipopolysaccharide
response to molecule of bacterial origin
monovalent inorganic cation transport
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
import into cell
response to bacterium
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis