ATP4B [The Human Chemical-Genetic Interaction Map Project]

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======= ATP4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP4B
  * **<color #00a2e8>Official Name</color>**: ATPase H+/K+ transporting subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=496|496]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51164|P51164]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137217|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity. {ECO:0000269|PubMed:19694409}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na K-ATPase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|potassium:proton exchanging ATPase activity|
|sodium:potassium-exchanging ATPase activity|
|sodium:potassium-exchanging ATPase complex|
|cellular potassium ion homeostasis|
|sodium ion export across plasma membrane|
|establishment or maintenance of transmembrane electrochemical gradient|
|cellular sodium ion homeostasis|
|ATPase activator activity|
|potassium ion homeostasis|
|sodium ion homeostasis|
|export across plasma membrane|
|potassium ion import across plasma membrane|
|positive regulation of ATPase activity|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|regulation of ATPase activity|
|sodium ion transmembrane transport|
|import across plasma membrane|
|cellular monovalent inorganic cation homeostasis|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|sodium ion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|monovalent inorganic cation transport|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|response to bacterium|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cation transport|
|response to lipid|
|cellular homeostasis|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|response to organonitrogen compound|
|export from cell|
|response to nitrogen compound|
|chemical homeostasis|
|transmembrane transport|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|ion transport|
|positive regulation of catalytic activity|
|response to oxygen-containing compound|
|homeostatic process|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.71|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.71|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13697
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP4B Expression in NALM6 Cells: 1.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>