NEFM
Gene Information
- Official Symbol: NEFM
- Official Name: neurofilament medium
- Aliases and Previous Symbols: N/A
- Entrez ID: 4741
- UniProt: P07197
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
- UniProt Summary: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3866
- Expression level (log2 read counts): -5.6
NEFM Expression in NALM6 Cells: -5.6
