Pomalidomide 20μM R07 exp391
Mechanism of Action
IMiD that targets neo-substrates IKZF1/3 for ubiquitination by CUL4A-DDB1-cereblon complex
- Class / Subclass 1: Proteostasis / Ubiquitin-Proteasome Activator
Technical Notes
Compound References
- PubChem Name: Pomalidomide
- Synonyms: CC-4047
- CAS #: 19171-19-8
- PubChem CID: 134780
- IUPAC: 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
- INCHI Name: InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
- INCHI Key: UVSMNLNDYGZFPF-UHFFFAOYSA-N
- Molecular Weight: 273.24
- Canonical SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N
- Isomeric SMILES: N/A
- Molecular Formula: C13H11N3O4
Compound Supplier
- Supplier Name: TCI America
- Catalog #: P2074
- Lot #: 3IUQJ-FB
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C13H11N3O4 274.08223; found 274.07926
Dose Response Curve
- Platform ID: Pomalidomide
- Min: -9.8487; Max: 7.7553
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 20µM
- Days of incubation: 8
- Doublings: 6.8
- Numbers of reads: 22978121
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/1 | Scores |
Pomalidomide 20μM R07 exp391
