TRIM44

Gene Information

Official Symbol: TRIM44
Official Name: tripartite motif containing 44
Aliases and Previous Symbols: N/A
Entrez ID: 54765
UniProt: Q96DX7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008].
UniProt Summary: May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807). {ECO:0000250, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:26394807}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0129480 7μM R02 exp85	-2.82
Cincreasin 100μM R08 exp473	-2.62
GSK626616 14μM R08 exp485	-2.5
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-2.37
AICAR 240μM R05 exp211	-2.27
L-BMAA 500 to 750μM on day4 R04 exp185	-2.25
Citral 75μM R06 exp275	-2.07
LJH685 5μM R02 exp73	-2.06
Pterostilbene 16μM R02 exp78	-2.04
Wortmannin 5μM R00 exp38	-1.98
A-395N 10μM R05 exp219	-1.97
Cyclosporin-A 0.8μM R07 exp347	-1.97
Artemisinin 50μM R08 exp450	-1.86
5-Azacytidine 2μM R07 exp330	-1.85
Nicotinamide Riboside 100μM R03 exp139	-1.84
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.78
EPZ-5676 30μM R05 exp233	-1.74
Taxol 0.002μM R01 exp54	-1.7
Trientine 500μM R08 exp534	-1.7
UNC2400 2μM R03 exp156	1.71
Mubritinib 0.2μM R01 exp48	1.72
Golgicide-A 2μM R03 exp121	1.75
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.79
HMS-I1 1μM R01 exp46	1.79
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.86
Hydroxychloroquine 30μM R08 exp490	1.99
Heregulin-B 44ng/ml R08 exp486	2.32
Pomalidomide 20μM R07 exp391	2.52
Q15 1 to 2μM on day4 R04 exp164	2.93
Lapatinib 5μM R01 exp47	3.06

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9398
Expression level (log2 read counts): 8.27

Expression Distribution

negative regulation of protein K48-linked ubiquitination
regulation of protein K48-linked ubiquitination
negative regulation of protein polyubiquitination
regulation of protein polyubiquitination
positive regulation of defense response to virus by host
regulation of defense response to virus by host
positive regulation of cytokine-mediated signaling pathway
positive regulation of response to cytokine stimulus
regulation of defense response to virus
negative regulation of protein ubiquitination
positive regulation of NIK/NF-kappaB signaling
negative regulation of protein modification by small protein conjugation or removal
regulation of NIK/NF-kappaB signaling
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
protein stabilization
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
regulation of protein stability
regulation of immune effector process
regulation of response to biotic stimulus
negative regulation of protein modification process
regulation of defense response
regulation of multi-organism process
zinc ion binding
positive regulation of intracellular signal transduction
negative regulation of cellular protein metabolic process
regulation of response to external stimulus
negative regulation of protein metabolic process
regulation of response to stress
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of signal transduction
regulation of immune system process
positive regulation of RNA metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
regulation of protein modification process