Wortmannin 5μM R00 exp38
Mechanism of Action
Inhibits PI3K and PI3K-related enzymes, non-specific covalent inhibitor
- Class / Subclass 1: Signal Transduction / Kinase Inhibitor
- Class / Subclass 2: Proteostasis / Autophagy Inhibitor
Technical Notes
Compound References
- PubChem Name: Wortmannin
- Synonyms: SL-2052; KY-12420
- CAS #: 19545-26-7
- PubChem CID: 312145
- IUPAC: [(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate
- INCHI Name: InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
- INCHI Key: QDLHCMPXEPAAMD-QAIWCSMKSA-N
- Molecular Weight: 428.4
- Canonical SMILES: CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
- Isomeric SMILES: CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C
- Molecular Formula: C23H24O8
Compound Supplier
- Supplier Name: LC Laboratories
- Catalog #: W-2990
- Lot #: SS-107
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C23H24O8 451.13634; found 451.1358
Dose Response Curve
- Platform ID: Wortmannin
- Min: -10.7381; Max: 63.3011
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 1.6783 |
| IC30 | 3.4255 |
| IC40 | 6.1479 |
| IC50 | 10.5153 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 00
- Dose: 5µM
- Days of incubation: 8
- Doublings: 3.4
- Numbers of reads: 12718276
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 30/18 | Scores |
Wortmannin 5μM R00 exp38
Wortmannin 0.5μM R00 exp37 vs Wortmannin 5μM R00 exp38
UM0129480 7μM R02 exp85 vs Wortmannin 5μM R00 exp38
CAY10603 0.55μM R08 exp467 vs Wortmannin 5μM R00 exp38
Dexamethasone 0.006μM R07 exp351 vs Wortmannin 5μM R00 exp38
GSK626616 14μM R08 exp485 vs Wortmannin 5μM R00 exp38
Cycloheximide 0.2μM R00 exp15 vs Wortmannin 5μM R00 exp38
Thapsigargin 0.005μM R07 exp407 vs Wortmannin 5μM R00 exp38
Lead acetate 2000μM R08 exp497 vs Wortmannin 5μM R00 exp38
Dorsomorphin 5μM R07 exp357 vs Wortmannin 5μM R00 exp38
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352 vs Wortmannin 5μM R00 exp38
WYE-354 6μM R02 exp90 vs Wortmannin 5μM R00 exp38
TRAIL 50ng/ml R00 exp36 vs Wortmannin 5μM R00 exp38
Alpha-Amanitin 0.5μM R00 exp5 vs Wortmannin 5μM R00 exp38
Ibrutinib 10μM R08 exp442 vs Wortmannin 5μM R00 exp38
TRAIL 5ng/ml R00 exp35 vs Wortmannin 5μM R00 exp38
