SMARCC1

Gene Information

Official Symbol: SMARCC1
Official Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Aliases and Previous Symbols: N/A
Entrez ID: 6599
UniProt: Q92922
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.225μM R08 exp444	-2.09
Phenformin 20μM R03 exp143	-1.9
BI-6727 0.04μM R03 exp98	-1.87
Ethambutol 25μM R08 exp481	1.72
Pyrazinamide 100μM R08 exp516	1.74
Temozolomide 200μM R04 exp189	1.76
Glyphosate 1000μM R06 exp283	1.77
Dexamethasone 0.006μM R07 exp351	1.79
LY2090314 0.003μM R08 exp499	1.79
Rapamycin 0.001μM R08 exp429	1.83
Lead acetate 2000μM R08 exp497	2
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.09
Rotenone 20μM R00 exp34	2.15
Cabazitaxel 0.001μM R05 exp223	2.31
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	2.32
FBS-Wisent 0.1 R07 exp426	2.59
TRAIL 50ng/ml R00 exp36	2.74
Wortmannin 5μM R00 exp38	2.99
I-BRD9 4μM R07 exp365	3.31

Global Fraction of Cell Lines Where Essential: 2/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1868
Expression level (log2 read counts): 8.51

Expression Distribution

Gene	Correlation
ARID1A	0.489
SMARCB1	0.425

SWIRM
Myb DNA-binding

npBAF complex
XY body
nBAF complex
nucleosome disassembly
chromatin disassembly
SWI/SNF complex
protein-DNA complex disassembly
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
prostate gland development
nucleosomal DNA binding
negative regulation of ubiquitin-dependent protein catabolic process
negative regulation of proteasomal protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
ATP-dependent chromatin remodeling
negative regulation of cellular protein catabolic process
insulin receptor signaling pathway
RNA polymerase II distal enhancer sequence-specific DNA binding
protein N-terminus binding
regulation of proteasomal ubiquitin-dependent protein catabolic process
histone binding
negative regulation of protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
cellular response to insulin stimulus
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
response to insulin
nuclear chromatin
protein-containing complex disassembly
protein-DNA complex subunit organization
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
cellular response to peptide hormone stimulus
transcription coactivator activity
negative regulation of catabolic process
urogenital system development
cellular response to peptide
negative regulation of proteolysis