Ethambutol 25μM R08 exp481
Mechanism of Action
Inhibits arabinosyl transferase, interferes with cell wall formation
- Class / Subclass 1: Infectious Disease / Antibiotic
Technical Notes
Compound References
- PubChem Name: Ethambutol Hydrochloride
- Synonyms: Emb dihydrochloride
- CAS #: 1070-11-7
- PubChem CID: 14051
- IUPAC: (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;dihydrochloride
- INCHI Name: InChI=1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
- INCHI Key: AUAHHJJRFHRVPV-BZDVOYDHSA-N
- Molecular Weight: 277.23
- Canonical SMILES: CCC(CO)NCCNC(CC)CO.Cl.Cl
- Isomeric SMILES: CC[C@@H](CO)NCCN[C@@H](CC)CO.Cl.Cl
- Molecular Formula: C10H26Cl2N2O2
Compound Supplier
- Supplier Name: Med Chem Express
- Catalog #: HY-B0535A
- Lot #: 13585
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C10H24N2O2 205.19105; found 205.19059
Dose Response Curve
- Platform ID: Ethambutol
- Min: -10.7445; Max: 28.8248
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 08
- Dose: 25µM
- Days of incubation: 8
- Doublings: 7.2
- Numbers of reads: 17949001
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Ethambutol 25μM R08 exp481
