DDX27

Entrez Summary: N/A
UniProt Summary: Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154). {ECO:0000269|PubMed:25825154}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 212/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	6/28
blood	9/28
bone	12/26
breast	10/33
central nervous system	19/56
cervix	0/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	4/16
kidney	1/21
liver	3/20
lung	25/75
lymphocyte	4/16
ovary	10/26
pancreas	10/24
peripheral nervous system	5/16
plasma cell	4/15
prostate	0/1
skin	7/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	3/29
uterus	3/5

Expression Distribution

Helicase C
DEAD

RNA helicase activity
chromosome
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
ATP binding
RNA metabolic process
gene expression