PT-1 25μM R07 exp392
Mechanism of Action
Activates AMPK, selectivefor ‘_1-complexes, may antagonize autoinhibition
- Class / Subclass 1: Signal Transduction / Kinase Activator
Technical Notes
Compound References
- PubChem Name: 2-Chloro-5-[[(5Z)-5-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]benzoic acid
- Synonyms: N/A
- CAS #: 331002-70-1
- PubChem CID: 135398518
- IUPAC: 2-chloro-5-[[(5Z)-5-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]benzoic acid
- INCHI Name: InChI=1S/C23H16ClN3O6S/c1-11-7-16(18(27(31)32)8-12(11)2)19-6-4-14(33-19)10-20-21(28)26-23(34-20)25-13-3-5-17(24)15(9-13)22(29)30/h3-10H,1-2H3,(H,29,30)(H,25,26,28)/b20-10-
- INCHI Key: RTHRCOIONCZINZ-JMIUGGIZSA-N
- Molecular Weight: 497.9
- Canonical SMILES: CC1=CC(=C(C=C1C)[N+](=O)[O-])C2=CC=C(O2)C=C3C(=O)NC(=NC4=CC(=C(C=C4)Cl)C(=O)O)S3
- Isomeric SMILES: CC1=CC(=C(C=C1C)[N+](=O)[O-])C2=CC=C(O2)/C=C\\3/C(=O)NC(=NC4=CC(=C(C=C4)Cl)C(=O)O)S3
- Molecular Formula: C23H16ClN3O6S
Compound Supplier
- Supplier Name: Tocris Bioscience
- Catalog #: 4039
- Lot #: 1B/207254
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C23H16ClN3O6S 498.05211; found 498.05338
Dose Response Curve
- Platform ID: PT-1
- Min: -13.9082; Max: 63.6419
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 80.8898 |
| IC30 | 86.1595 |
| IC40 | 92.2118 |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 25µM
- Days of incubation: 8
- Doublings: 6.9
- Numbers of reads: 23662909
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 1/0 | Scores |
PT-1 25μM R07 exp392
Golgicide-A 2μM R03 exp121 vs PT-1 25μM R07 exp392
L-BMAA 500 to 750μM on day4 R04 exp185 vs PT-1 25μM R07 exp392
