USP27X

Entrez Summary: This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016].
UniProt Summary: Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK- degradation signal. By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity. {ECO:0000250|UniProtKB:Q8CEG8}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	-2.23
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.21
Sulforaphane 9μM R08 exp525	-1.96
Thimerosal 0.85μM R08 exp529	-1.83
Hinokiflavone 12μM R08 exp487	-1.73
Q15 1 to 2μM on day4 R04 exp164	-1.72
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.72
Asunaprenir 3μM R07 exp336	1.74
Vitamin-D3 40μM R08 exp536	1.77
Rifampicin 10μM R00 exp32	1.82
Betulinic acid 10 to 15μM on day4 R05 exp222	1.9
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.96
CoCl2 18μM R07 exp346	1.98
Genistein 15μM R07 exp360	1.99
Bortezomib 0.005μM R00 exp6	2.03
VHL-ligand-1 20μM R07 exp421	2.03
EPZ-5676 30μM R05 exp233	2.04
Tubastatin-A 2.5μM R07 exp417	2.09
L-BMAA 500 to 750μM on day4 R04 exp185	2.15
Alpha-Amanitin 0.5μM R00 exp5	2.2
Heregulin-B 44ng/ml R08 exp486	2.22
I-BRD9 4μM R07 exp365	2.23
Cycloheximide 0.2μM R00 exp15	2.3
PT-1 25μM R07 exp392	2.37
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.43
CCCP 0.1μM R00 exp10	2.52
Nutlin-3A 1.6μM R06 exp294	2.53
Lead acetate 990μM R08 exp496	2.55
Benzoate 20000μM R08 exp456	2.72
Actinomycin-D 0.01μM R00 exp4	2.97
AICAR 240μM R05 exp211	3.22

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Lys63-specific deubiquitinase activity
Lys48-specific deubiquitinase activity
protein K63-linked deubiquitination
protein K48-linked deubiquitination
thiol-dependent ubiquitin-specific protease activity
protein stabilization
protein deubiquitination
regulation of protein stability
protein modification by small protein removal
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
positive regulation of apoptotic process
positive regulation of programmed cell death
protein catabolic process
positive regulation of cell death
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
organic substance catabolic process
cellular catabolic process