Rifampicin 10μM R00 exp32
Mechanism of Action
Inhibits bacterial RNA polymerase, induces hepatic cytochrome P450 enzymes
- Class / Subclass 1: Infectious Disease / Antibiotic
Technical Notes
Compound References
- PubChem Name: Rifampicin
- Synonyms: Rifampin; Rifamycin AMP
- CAS #: 13292-46-1
- PubChem CID: 135398735
- IUPAC: [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
- INCHI Name: InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
- INCHI Key: JQXXHWHPUNPDRT-WLSIYKJHSA-N
- Molecular Weight: 822.9
- Canonical SMILES: CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C)C
- Isomeric SMILES: C[C@H]1/C=C/C=C(\\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C
- Molecular Formula: C43H58N4O12
Compound Supplier
- Supplier Name: Med Chem Express
- Catalog #: HY-B0272
- Lot #: 33587
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C43H58N4O12 823.4124; found 823.4128
Dose Response Curve
- Platform ID: Rifampicin
- Min: -17.8934; Max: 5.5857
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 00
- Dose: 10µM
- Days of incubation: 8
- Doublings: 6.1
- Numbers of reads: 9970595
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 3/2 | Scores |
Rifampicin 10μM R00 exp32
Rifampicin 10μM R00 exp32 vs Wortmannin 0.5μM R00 exp37
DABN 2μM R00 exp16 vs Rifampicin 10μM R00 exp32
Cycloheximide 0.2μM R00 exp15 vs Rifampicin 10μM R00 exp32
2-Methoxyestradiol 0.55μM R07 exp310 vs Rifampicin 10μM R00 exp32
Alpha-Amanitin 0.5μM R00 exp5 vs Rifampicin 10μM R00 exp32
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Rifampicin 10μM R00 exp32
