RREB1

Gene Information

Official Symbol: RREB1
Official Name: ras responsive element binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 6239
UniProt: Q92766
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
3-Bromopyruvate 7μM R04 exp175	-2.18
CCCP 0.1μM R00 exp10	-2.17
Bafilomycin-A1 0.009μM R08 exp454	-2.03
Rifampicin 10μM R00 exp32	-1.99
Tubacin 1.6μM R07 exp416	-1.98
Bisphenol F 50μM R08 exp457	1.7
All-trans-Retinoic-Acid 40μM R07 exp334	1.72
Ammonium tetrathiomolybdate 10μM R08 exp448	1.81
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.82
INK128 0.2μM R02 exp70	2.24

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12987
Expression level (log2 read counts): 6.64

Expression Distribution

Gene	Correlation
RBM26	0.453
ARID4B	0.42

positive regulation of wound healing, spreading of epidermal cells
regulation of wound healing, spreading of epidermal cells
positive regulation of lamellipodium morphogenesis
positive regulation of mammary gland epithelial cell proliferation
regulation of lamellipodium morphogenesis
regulation of mammary gland epithelial cell proliferation
positive regulation of lamellipodium organization
positive regulation of morphogenesis of an epithelium
positive regulation of substrate adhesion-dependent cell spreading
regulation of lamellipodium organization
regulation of substrate adhesion-dependent cell spreading
positive regulation of wound healing
positive regulation of response to wounding
positive regulation of cell-substrate adhesion
fibrillar center
regulation of wound healing
positive regulation of epithelial cell migration
positive regulation of cell morphogenesis involved in differentiation
regulation of response to wounding
regulation of morphogenesis of an epithelium
positive regulation of epithelial cell proliferation
regulation of cell-substrate adhesion
regulation of epithelial cell migration
Ras protein signal transduction
nuclear body
regulation of cell morphogenesis involved in differentiation
RNA polymerase II regulatory region sequence-specific DNA binding
small GTPase mediated signal transduction
regulation of epithelial cell proliferation
positive regulation of cell projection organization
nuclear speck
positive regulation of cell adhesion
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
regulation of cell morphogenesis
positive regulation of cell migration
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of cell development