ARID4B

Gene Information

Official Symbol: ARID4B
Official Name: AT-rich interaction domain 4B
Aliases and Previous Symbols: N/A
Entrez ID: 51742
UniProt: Q4LE39
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 5ng/ml R00 exp35	-3.86
Bortezomib 0.05μM R00 exp7	-3.73
BML-284 0.09μM R08 exp460	-3.52
UMK57 1μM R01 exp59	-3.31
Bortezomib 0.005μM R00 exp6	-3.14
TRAIL 50ng/ml R00 exp36	-3.09
Pimelic-diphenylamide-106 5μM R00 exp28	-2.96
HMS-I1 1μM R01 exp46	-2.72
Apcin 25μM plus proTAME 2μM R04 exp177	-2.71
CFI-400945 25μM R08 exp469	-2.71
BI-D1870 3.15μM R02 exp66	-2.44
Rotenone 20μM R00 exp34	-2.35
Quercetin 20μM R08 exp517	-2.32
Vinblastine 0.002μM R01 exp60	-2.3
Chloroquine 32μM R08 exp470	-2.26
CCT251545 0.2μM R06 exp271	-2.22
Bafilomycin-A1 0.009μM R08 exp454	-2.14
S-trityl-L-cysteine 0.5μM R05 exp243	-2.12
Artemisinin 50μM R08 exp450	-1.98
A-196 10μM R03 exp114	-1.97
Cryptotanshinone 12μM R05 exp227	-1.89
RO-3307 4.7μM R02 exp80	-1.88
MLN-4924 2μM R00 exp22	-1.87
BI-6727 0.0125μM R03 exp97	-1.86
Mdivi-1 15μM R05 exp217	-1.83
CoCl2 18μM R07 exp346	-1.71
Chlorpromazine 10μM R07 exp344	-1.7
All-trans-Retinoic-Acid 40μM R07 exp334	1.71
Amiloride 100μM R08 exp447	1.74
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.74
CB-839 10μM R05 exp224	1.77
Arsenic trioxide 60μM R08 exp449	1.78
UM0129480 7μM R02 exp85	1.83
GSK-J4 1-1.25μM to day4 R07 exp363	1.86
Mubritinib 0.2μM R02 exp65	1.87
HMS-I2 10μM R06 exp288	1.97
Rapamycin 2μM plus FK-506 5μM R07 exp308	2.01
Deguelin 0.15μM R05 exp209	2.03
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.04
IWR1 50μM R08 exp495	2.08
Rapamycin 1μM R00 exp29	2.11
Olaparib 4μM R08 exp512	2.19
ML-792 0.2μM R08 exp505	2.22
Epothilone-B 0.0015μM R05 exp231	2.31
iCRT14 30μM R08 exp492	2.34
Citral 50μM R06 exp274	2.35
Rapamycin 0.001μM R08 exp429	2.37
Lapatinib 5μM R01 exp47	2.41
Nifuroxazide 1μM R01 exp51	2.43
Rapamycin 2μM R07 exp306	2.47
Doxycycline 10μM R00 exp18	2.48
Torin1 0.08μM R02 exp82	2.55
Dinaciclib 0.007μM R07 exp355	2.59
GSK-J4 1μM R07 exp362	2.65
Benzoate 10000μM R08 exp455	2.74
LB-100 2μM R05 exp210	2.83
Pyridostatin 4μM R05 exp240	2.85
2-Deoxy-D-glucose 800μM R05 exp214	2.91
Temozolomide 200μM R04 exp189	2.96
Lead acetate 2000μM R08 exp497	3.14
Cytochalasin-B 5μM R07 exp349	3.17
Erlotinib 10μM R05 exp216	3.21
Staurosporine 0.02μM R08 exp524	3.21
Latrunculin-B 10μM R07 exp374	3.38
UM0131023 0.05μM R05 exp248	3.42
Oligomycin-A 2μM R00 exp25	3.43
Trimetrexate 0.03μM R08 exp535	3.44
Lead acetate 2000μM R08 exp498 no dilution day6	3.48
Etoposide 0.1μM R05 exp198	3.55
Hypoxia 5%O2 R04 exp191	3.93
Betulinic acid 10 to 15μM on day4 R05 exp222	3.94
Rapamycin 10μM R00 exp30	4.36
Ethanol 0.01 R05 exp234	5.29

Gene	Correlation
PDS5B	0.685
ANP32A	0.571
BRMS1	0.57
BRD1	0.551
KDM6A	0.495
ING1	0.489
FAM204A	0.483
TSPYL1	0.472
SAP130	0.468
PCGF1	0.467
RBM26	0.461
CNOT2	0.46
ITPK1	0.447
CDC5L	0.439
CCDC130	0.429
KLHDC2	0.426
C9orf78	0.426
CTNNBL1	0.421
RREB1	0.42
ARID4A	0.419
HNRNPU	0.414
ESCO1	0.409
EIF4B	0.407
MEMO1	0.406
WBP11	0.405
CYB561A3	0.402

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15403
Expression level (log2 read counts): 6.65

Expression Distribution

RBB1NT
Tudor-knot
ARID

establishment of Sertoli cell barrier
histone H3-K9 trimethylation
histone H4-K20 trimethylation
histone H4-K20 methylation
Sertoli cell development
histone H3-K9 methylation
regulation of gene expression by genetic imprinting
histone H3-K9 modification
Sertoli cell differentiation
genetic imprinting
peptidyl-lysine trimethylation
histone lysine methylation
peptidyl-lysine methylation
histone methylation
male gonad development
protein alkylation
protein methylation
development of primary male sexual characteristics
male sex differentiation
epithelial cell development
gonad development
development of primary sexual characteristics
transcription regulatory region DNA binding
regulation of gene expression, epigenetic
macromolecule methylation
sex differentiation
methylation
peptidyl-lysine modification
histone modification
covalent chromatin modification
reproductive structure development
reproductive system development
cellular component
spermatogenesis
male gamete generation
developmental process involved in reproduction
epithelial cell differentiation
gamete generation
chromatin organization
molecular function