Mubritinib 0.2μM R02 exp65 [The Human Chemical-Genetic Interaction Map Project]

Inhibits HER2 (Erb2) EGFR receptor tyrosine kinase

Class / Subclass 1: Signal Transduction / Kinase Inhibitor

Compound References

PubChem Name: Mubritinib
Synonyms: TAK-165
CAS #: 366017-09-6
PubChem CID: 6444692
IUPAC: 4-[[4-[4-(triazol-1-yl)butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole
INCHI Name: InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
INCHI Key: ZTFBIUXIQYRUNT-MDWZMJQESA-N
Molecular Weight: 468.5
Canonical SMILES: C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F
Isomeric SMILES: C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)/C=C/C4=CC=C(C=C4)C(F)(F)F
Molecular Formula: C25H23F3N4O2

Compound Supplier

Supplier Name: Selleck Chemicals
Catalog #: S2216
Lot #: N/A

Compound Characterization

LCMS: Tr 1.31 min, m/z 469+ [M+H]+

Dose Response Curve

Platform ID: MUTRITINIB
Min: -5.4651; Max: 38.1718

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 02
Dose: 200nM
Days of incubation: 8
Doublings: 3.5
Numbers of reads: 11836345

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
3/11	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
HK1	-3.36	<0.01
GOT1	-3.34	<0.01
PDXK	-3.01	<0.01
CDC20	-2.99	0.30
CDIPT	-2.87	0.30
AHCYL1	-2.77	0.06
BSG	-2.66	0.07
TBCD	-2.43	0.30
SARS	-2.40	0.63
OR5P3	-2.27	0.33
CPSF7	-2.25	0.30
RBM14	-2.25	0.30
BCAT1	-2.24	0.30
RBM14-RBM4	-2.22	0.30
UBE2QL1	-2.19	0.30
ACACA	-2.19	0.30
WSB1	-2.11	0.58
SCN3A	-2.10	0.34
PGP	-2.10	0.30
C17orf64	-2.07	0.30
PNP	-2.07	0.30
ZNF169	-2.05	0.30
GPD2	-2.04	0.30
TACR3	-2.01	0.33
ADAM28	-2.00	0.33
ARHGAP1	-2.00	0.42
RBMX	-1.98	0.52
LOC147646	-1.97	0.43
C15orf27	-1.95	0.39
GLIS2	-1.95	0.45
TMEM165	2.30	0.08
PARS2	2.31	0.11
MRPS27	2.34	0.15
CLUH	2.35	0.07
ATP5F1	2.35	0.07
RNASEH1	2.36	0.06
DPH3	2.36	0.07
ZNF812	2.36	0.07
LARS2	2.36	0.07
ENY2	2.42	0.09
RBM33	2.45	0.08
DARS2	2.46	0.08
LUC7L3	2.48	0.17
DIAPH3	2.51	0.07
NR2C2AP	2.51	0.07
PREPL	2.52	0.06
FASTKD1	2.53	0.06
PRKAG1	2.57	0.02
AKAP12	2.57	0.07
TOP1MT	2.68	0.08
POLG	2.93	<0.01
IPPK	3.18	<0.01
PGM3	3.19	<0.01
CXorf56	3.21	<0.01
POLRMT	3.23	<0.01
PTMA	3.30	0.01
IPMK	3.41	<0.01
SLC7A1	3.41	<0.01
ACSL3	3.64	<0.01
SLC25A51	5.04	<0.01

Screen	Correlation	Plot
Rotenone 0.07μM R08 exp431	0.114	View
QNZ 0.01μM R05 exp241	0.093	View
QNZ 0.01μM R08 exp439	0.083	View
Phenformin 20μM R05 exp212	0.079	View
Oligomycin-A 2μM R00 exp25	0.068	View
iCRT14 30μM R08 exp492	0.064	View
NMS-873 0.07μM R07 exp380	0.059	View
Mubritinib 0.2μM R01 exp48	0.119	View
Chloramphenicol 20μM R00 exp13	0.094	View

GO Term	Fold Change	Genes
NAD transmembrane transport	276.40	SLC25A51,SLC25A52
NAD transmembrane transporter activity	276.40	SLC25A51,SLC25A52
mitochondrial gene expression	19.88	POLRMT,FASTKD1,DARS2,LARS2,MRPS27
mitochondrial matrix	11.64	POLRMT,POLG,TOP1MT,FASTKD1,DARS2,LARS2,ATP5PB,MRPS27,PARS2,NDUFA10

Last modified: 2026/01/15 21:36
by 127.0.0.1