GPD2

Entrez Summary: The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DAO
FAD oxidored

sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
glycerophosphate shuttle
glycerol-3-phosphate dehydrogenase (quinone) activity
glycerol-3-phosphate dehydrogenase [NAD+] activity
glycerol-3-phosphate dehydrogenase complex
glycerol-3-phosphate catabolic process
NADH oxidation
glycerol catabolic process
alditol catabolic process
glycerol-3-phosphate metabolic process
alditol phosphate metabolic process
glycerol metabolic process
alditol metabolic process
polyol catabolic process
NADH metabolic process
cellular carbohydrate catabolic process
gluconeogenesis
NAD metabolic process
hexose biosynthetic process
monosaccharide biosynthetic process
alcohol catabolic process
cellular ketone metabolic process
organic hydroxy compound catabolic process
primary alcohol metabolic process
multicellular organism growth
polyol metabolic process
respiratory electron transport chain
glucose metabolic process
carbohydrate catabolic process
carbohydrate biosynthetic process
organophosphate catabolic process
hexose metabolic process
cellular respiration
cellular carbohydrate metabolic process
electron transport chain
carbohydrate derivative catabolic process
monosaccharide metabolic process
energy derivation by oxidation of organic compounds
camera-type eye development
alcohol metabolic process