PGP

Entrez Summary: N/A
UniProt Summary: Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity). {ECO:0000250|UniProtKB:Q8CHP8, ECO:0000269|PubMed:26755581}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phenformin 20μM R03 exp143	-2.7
Oligomycin-A 2μM R00 exp25	-2.66
Rotenone 0.07μM R08 exp431	-2.16
Mubritinib 0.2μM R02 exp65	-2.1
Methotrexate 0.01μM R08 exp501	-1.95
Nifurtimox 1μM R03 exp141	-1.91
Phenformin 20μM R05 exp212	-1.89
QNZ 0.01μM R05 exp241	-1.7
CFI-400945 25μM R08 exp469	1.71
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.73
BML-284 0.09μM R08 exp460	1.74
Atovaquone 15μM R08 exp451	1.77
Docosahexaenoic-acid 50μM R07 exp356	1.79
3-Bromopyruvate 7μM R04 exp175	1.83
LLY-283 2.6μM R06 exp290	1.86
Clomiphene 4.4μM R02 exp68	1.91
Cytochalasin-B 5μM R07 exp349	1.91
Trichostatin-A 0.06μM R07 exp415	1.91
Bafilomycin-A1 0.009μM R08 exp454	1.92
Milciclib 2μM R08 exp502	1.96
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.04
Genistein 15μM R07 exp360	2.13
Etoposide 0.1μM R05 exp198	2.2
Arsenate 40μM R06 exp264	2.52
Demecolcine 0.03μM R05 exp228	2.58
Talazoparib 0.006μM R06 exp299	2.61
Deferoxamine 11μM R07 exp350	2.79
Bortezomib 0.005μM R00 exp6	2.95
UM0125461 0.74μM R02 exp84	3.02
Centrinone 0.5μM R07 exp343	3.25
Nutlin-3A 1.6μM R06 exp294	3.81
Trimetrexate 0.03μM R08 exp535	4.3
Q15 2.7μM R02 exp79	5.6

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glycerol-1-phosphatase activity
glycerol-3-phosphatase activity
phosphoglycolate phosphatase activity
glycerol biosynthetic process
nucleotide phosphatase activity, acting on free nucleotides
alditol biosynthetic process
negative regulation of gluconeogenesis
glycerol metabolic process
alditol metabolic process
negative regulation of cellular carbohydrate metabolic process
regulation of gluconeogenesis
phosphatase activity
negative regulation of carbohydrate metabolic process
polyol biosynthetic process
cellular carbohydrate biosynthetic process
negative regulation of small molecule metabolic process
regulation of carbohydrate biosynthetic process
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
polyol metabolic process
alcohol biosynthetic process
regulation of glucose metabolic process
carbohydrate biosynthetic process
regulation of cellular carbohydrate metabolic process
cellular carbohydrate metabolic process
organic hydroxy compound biosynthetic process
regulation of carbohydrate metabolic process
protein dephosphorylation
magnesium ion binding
glycerophospholipid metabolic process
dephosphorylation
alcohol metabolic process
phospholipid metabolic process
glycerolipid metabolic process
regulation of small molecule metabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
small molecule biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process