UM0125461 0.74μM R02 exp84

Unknown

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
40/100	Scores	View	View	View	View	View

Screen	Correlation	Plot
Vemurafenib 6.6μM R02 exp89	0.07	View
Vemurafenib 6.6μM R08 exp434	0.068	View
iCRT14 30μM R08 exp492	0.056	View
Tubacin 1.6μM R07 exp416	0.149	View
Hydroxyurea 100μM R07 exp329	0.13	View
Thimerosal 0.85μM R08 exp529	0.12	View
Oligomycin-A 2μM R00 exp25	0.118	View
Artemisinin 50μM R08 exp450	0.097	View
Pterostilbene 16μM R02 exp78	0.094	View
Genistein 15μM R07 exp360	0.084	View
Dynasore 10μM R04 exp180	0.079	View
Deferoxamine 11μM R07 exp350	0.077	View
Q15 2.7μM R02 exp79	0.069	View
Quercetin 20μM R08 exp517	0.067	View
GSK-J4 1.5μM R08 exp441	0.066	View
Aphidicolin 0.4μM R08 exp440	0.065	View
LLY-283 2.6μM R06 exp290	0.065	View
PU-H71 1μM R08 exp515	0.063	View
BI-D1870 3.15μM R02 exp66	0.062	View
Q15 1 to 2μM on day4 R04 exp164	0.061	View
Dynasore 7μM R08 exp436	0.061	View
HMS-I2 10μM R06 exp288	0.061	View
Atovaquone 15μM R08 exp451	0.057	View
Arsenate 40μM R06 exp264	0.057	View
Docosahexaenoic-acid 50μM R07 exp356	0.056	View
LY2090314 0.003μM R08 exp500 no dilution day6	0.053	View
CB-5083 0.4μM R08 exp468	0.051	View
Tanespimycin 14μM R08 exp527	0.051	View

GO Term	Fold Change	Genes
GATOR1 complex	691.00	NPRL3,NPRL2
palmitoyl-CoA ligase activity	691.00	ACSL4,ACSL3
Seh1-associated complex	296.14	DEPDC5,NPRL3,NPRL2
negative regulation of TORC1 signaling	84.27	DEPDC5,PRKAA1,NPRL3,SESN2,NPRL2
cellular response to amino acid starvation	71.98	DEPDC5,NPRL3,EIF2S1,SESN2,NPRL2
response to amino acid starvation	67.75	DEPDC5,NPRL3,EIF2S1,SESN2,NPRL2
negative regulation of TOR signaling	52.35	DEPDC5,PRKAA1,NPRL3,SESN2,NPRL2
regulation of TORC1 signaling	40.17	DEPDC5,PRKAA1,NPRL3,SESN2,NPRL2
positive regulation of autophagy	28.40	DEPDC5,SPTLC2,PRKAA1,NPRL3,SESN2,NPRL2
regulation of TOR signaling	25.59	DEPDC5,PRKAA1,NPRL3,SESN2,NPRL2
cellular response to starvation	24.25	DEPDC5,PRKAA1,NPRL3,EIF2S1,SESN2,NPRL2
lipid homeostasis	22.29	LDLRAP1,PRKAA1,LDLR,FBXW7,SESN2
response to starvation	19.74	DEPDC5,PRKAA1,NPRL3,EIF2S1,SESN2,NPRL2
cellular response to nutrient levels	17.79	DEPDC5,PRKAA1,NPRL3,EIF2S1,SESN2,NPRL2
cellular response to extracellular stimulus	15.82	DEPDC5,PRKAA1,NPRL3,EIF2S1,SESN2,NPRL2
positive regulation of cellular catabolic process	15.45	DEPDC5,SPTLC2,PRKAA1,NPRL3,CNOT2,SESN2,NPRL2
regulation of autophagy	13.90	DEPDC5,SPTLC2,PRKAA1,NPRL3,FBXW7,SESN2,NPRL2
positive regulation of catabolic process	12.08	DEPDC5,SPTLC2,PRKAA1,NPRL3,LDLR,CNOT2,FBXW7,SESN2,NPRL2
regulation of cellular catabolic process	9.66	DEPDC5,SPTLC2,PRKAA1,NPRL3,LDLR,CNOT2,FBXW7,SESN2,NPRL2

GO Term	Fold Change	Genes
mitochondrial RNA modification	184.27	TRIT1,HSD17B10,RPUSD4
mitochondrial tRNA processing	127.57	TRIT1,HSD17B10,RPUSD4
positive regulation of mitochondrial translation	110.56	COA3,FASTKD2,RPUSD4
mitochondrial RNA processing	110.56	TRIT1,HSD17B10,FASTKD2,RPUSD4
tRNA threonylcarbamoyladenosine metabolic process	97.55	TRIT1,HSD17B10,RPUSD4
heme biosynthetic process	66.34	HMBS,ALAS1,IBA57
porphyrin-containing compound biosynthetic process	59.23	HMBS,ALAS1,IBA57
regulation of mitochondrial gene expression	59.23	COA3,FASTKD2,RPUSD4
tetrapyrrole biosynthetic process	59.23	HMBS,ALAS1,IBA57
mitochondrial RNA metabolic process	51.42	TRIT1,HSD17B10,FASTKD2,RPUSD4
mitochondrial gene expression	19.88	TRIT1,HSD17B10,FASTKD2,RPUSD4,MRPS34
mitochondrial matrix	9.31	TRIT1,ALAS1,IBA57,HSD17B10,FASTKD2,MIPEP,RPUSD4,MRPS34
RNA processing	5.97	MBNL1,TRIT1,AHCYL1,HSD17B10,STRAP,PIH1D1,FASTKD2,CELF2,RPUSD4