PCYT2

Entrez Summary: N/A
UniProt Summary: Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 20μM R08 exp466	-3
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.9
Q15 1 to 2μM on day4 R04 exp164	-2.89
Vemurafenib 6.6μM R02 exp89	-2.75
UM0125461 0.74μM R02 exp84	-2.59
Daidzin 10μM R06 exp280	-2.3
IU1-47 25μM R04 exp182	-2.21
GSK-J4 1μM R07 exp362	-2.19
Dynasore 10μM R04 exp180	-2.06
Bafilomycin-A1 0.009μM R08 exp454	-2.02
GSK-J4 1-1.25μM to day4 R07 exp363	-2
Thapsigargin 0.005μM R07 exp407	-2
GSK-J5 1.5μM R08 exp484	-1.97
UM0011500 5μM R05 exp245	-1.89
Tubacin 1.6μM R07 exp416	-1.88
Vemurafenib 6.6μM R08 exp434	-1.81
Heregulin-B 44ng/ml R08 exp486	-1.8
Bisphenol A 100μM R06 exp269	-1.79
Chlorpromazine 10μM R07 exp344	-1.79
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.76
Resveratrol 16μM R03 exp147	-1.76
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.74
Sucrose 20000μM R06 exp298	-1.72
PU-H71 1μM R08 exp515	1.71
KU-0063794 3.8μM R02 exp71	1.76
RK-33 8μM R08 exp518	1.86
HMS-I1 1μM R01 exp46	2.06
GSK591 2.6μM R03 exp128	2.16
BI-6727 0.0125μM R03 exp97	2.21

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ethanolamine-phosphate cytidylyltransferase activity
phosphatidylethanolamine biosynthetic process
phosphatidylethanolamine metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
cellular component
organophosphate biosynthetic process
lipid biosynthetic process
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
lipid metabolic process