Daidzin 10μM R06 exp280
Mechanism of Action
Isoflavone from soy bean, putative ALDH inhibitor
- Class / Subclass 1: Uncharacterized Mechanism / Natural Product
- Class / Subclass 2: Metabolism / Metabolic Enzyme Inhibitor
Technical Notes
Compound References
- PubChem Name: Daidzin
- Synonyms: Daidzoside; NPI-031D; Daidzein 7-O-glucoside
- CAS #: 552-66-9
- PubChem CID: 107971
- IUPAC: 3-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
- INCHI Name: InChI=1S/C21H20O9/c22-8-16-18(25)19(26)20(27)21(30-16)29-12-5-6-13-15(7-12)28-9-14(17(13)24)10-1-3-11(23)4-2-10/h1-7,9,16,18-23,25-27H,8H2/t16-,18-,19+,20-,21-/m1/s1
- INCHI Key: KYQZWONCHDNPDP-QNDFHXLGSA-N
- Molecular Weight: 416.4
- Canonical SMILES: C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)OC4C(C(C(C(O4)CO)O)O)O)O
- Isomeric SMILES: C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O
- Molecular Formula: C21H20O9
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: D103530
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H20O9 417.11801; found 417.11768
Dose Response Curve
- Platform ID: Daidzin
- Min: -31.6006; Max: -7.0783
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 06
- Dose: 10µM
- Days of incubation: 8
- Doublings: 7.1
- Numbers of reads: 7702892
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Daidzin 10μM R06 exp280
Daidzin 10μM R06 exp280 vs SB203580 25μM R03 exp149
