STXBP1
Gene Information
- Official Symbol: STXBP1
- Official Name: syntaxin binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6812
- UniProt: P61764
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010].
- UniProt Summary: May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Pfam Domains GO Terms
Pfam Domains
| Sec1 |
GO Terms
| positive regulation of vesicle docking |
| regulation of vesicle docking |
| regulation of acrosomal vesicle exocytosis |
| positive regulation of glutamate secretion, neurotransmission |
| axon target recognition |
| regulation of glutamate secretion, neurotransmission |
| presynaptic dense core vesicle exocytosis |
| neuronal dense core vesicle exocytosis |
| negative regulation of synaptic transmission, GABAergic |
| dense core granule exocytosis |
| regulation of synaptic vesicle priming |
| regulation of synaptic vesicle fusion to presynaptic active zone membrane |
| SNARE complex assembly |
| positive regulation of glutamate secretion |
| presynaptic active zone membrane |
| regulation of SNARE complex assembly |
| synaptic vesicle maturation |
| platelet alpha granule |
| positive regulation of mast cell activation involved in immune response |
| synaptic vesicle priming |
| positive regulation of mast cell degranulation |
| regulation of glutamate secretion |
| phospholipase binding |
| long-term synaptic depression |
| positive regulation of amino acid transport |
| calcium ion-regulated exocytosis of neurotransmitter |
| positive regulation of calcium ion-dependent exocytosis |
| regulation of acrosome reaction |
| positive regulation of mast cell activation |
| positive regulation of neurotransmitter secretion |
| positive regulation of leukocyte degranulation |
| syntaxin-1 binding |
| regulation of fertilization |
| glutamate secretion |
| positive regulation of myeloid leukocyte mediated immunity |
| regulation of amino acid transport |
| regulation of vesicle fusion |
| positive regulation of synaptic transmission, glutamatergic |
| regulation of synaptic transmission, GABAergic |
| neuromuscular synaptic transmission |
| positive regulation of organic acid transport |
| regulation of mast cell degranulation |
| regulation of mast cell activation involved in immune response |
| positive regulation of amine transport |
| positive regulation of neurotransmitter transport |
| calcium-ion regulated exocytosis |
| vesicle docking involved in exocytosis |
| regulation of calcium ion-dependent exocytosis |
| platelet aggregation |
| regulation of mast cell activation |
| acidic amino acid transport |
| regulation of leukocyte degranulation |
| positive regulation of anion transport |
| positive regulation of regulated secretory pathway |
| syntaxin binding |
| regulation of myeloid leukocyte mediated immunity |
| regulation of organic acid transport |
| homotypic cell-cell adhesion |
| phagocytic vesicle |
| negative regulation of synaptic transmission |
| vesicle docking |
| synaptic vesicle exocytosis |
| SNARE binding |
| exocytic process |
| regulation of synaptic transmission, glutamatergic |
| vesicle fusion |
| organelle membrane fusion |
| regulation of synaptic vesicle exocytosis |
| dicarboxylic acid transport |
| acid secretion |
| postsynapse |
| positive regulation of exocytosis |
| regulation of amine transport |
| regulation of anion transport |
| organelle fusion |
| signal release from synapse |
| neurotransmitter secretion |
| regulation of neurotransmitter secretion |
| protein N-terminus binding |
| regulation of synaptic vesicle cycle |
| synaptic vesicle cycle |
| amino acid transport |
| platelet degranulation |
| vesicle-mediated transport in synapse |
| negative regulation of protein complex assembly |
| membrane fusion |
| positive regulation of leukocyte mediated immunity |
| response to estradiol |
| platelet activation |
| regulation of neurotransmitter transport |
| negative regulation of neuron apoptotic process |
| positive regulation of synaptic transmission |
| regulation of reproductive process |
| cellular response to interferon-gamma |
| regulation of regulated secretory pathway |
| signal release |
| organelle localization by membrane tethering |
| protein stabilization |
| membrane docking |
| neurotransmitter transport |
| response to interferon-gamma |
| protein localization to plasma membrane |
| regulation of synaptic plasticity |
| regulation of leukocyte mediated immunity |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| positive regulation of intracellular transport |
| positive regulation of immune effector process |
| regulation of exocytosis |
| protein localization to cell periphery |
| developmental maturation |
| protein domain specific binding |
| positive regulation of ion transport |
| regulation of protein stability |
| carboxylic acid transport |
| organic acid transport |
| blood coagulation |
| coagulation |
| axon |
| hemostasis |
| vesicle organization |
| regulation of neuron death |
| glutamatergic synapse |
| regulation of intracellular transport |
| regulation of neurotransmitter levels |
| cytoskeleton |
| axonogenesis |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| axon development |
| positive regulation of cell activation |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of secretion |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of protein complex assembly |
| organic anion transport |
| synaptic signaling |
| protein kinase binding |
| regulation of immune effector process |
| wound healing |
| protein localization to membrane |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of body fluid levels |
| cell-cell adhesion |
| cell part morphogenesis |
| regulation of vesicle-mediated transport |
| cell morphogenesis involved in differentiation |
| response to wounding |
| organelle localization |
| anion transport |
| protein-containing complex |
| regulation of leukocyte activation |
| regulation of cell activation |
| neuron projection development |
| developmental process involved in reproduction |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulated exocytosis |
| negative regulation of cellular component organization |
| cell morphogenesis |
| regulation of secretion by cell |
| innate immune response |
| regulation of multi-organism process |
| exocytosis |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| cellular protein-containing complex assembly |
| response to lipid |
| membrane organization |
| positive regulation of immune response |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| cell adhesion |
| biological adhesion |
| defense response to other organism |
| regulation of cellular component biogenesis |
| positive regulation of transport |
| negative regulation of cell death |
| secretion by cell |
| cellular response to cytokine stimulus |
| neuron differentiation |
| export from cell |
| identical protein binding |
| cell activation |
| response to cytokine |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| secretion |
| regulation of immune response |
| positive regulation of immune system process |
| cell projection organization |
| mitochondrion |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| RNA binding |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| protein transport |
| generation of neurons |
| peptide transport |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| cell development |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Daidzin 10μM R06 exp280 | -2.43 |
| NFN1 0.1μM R01 exp49 | -1.81 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 1/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10981
- Expression level (log2 read counts): 3.93
Expression Distribution
STXBP1 Expression in NALM6 Cells: 3.93
