CPEB2

Entrez Summary: N/A
UniProt Summary: May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0, ECO:0000269|PubMed:26398195}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of cytoplasmic translational elongation
negative regulation of translational elongation
negative regulation of cytoplasmic translation
messenger ribonucleoprotein complex
regulation of cytoplasmic translational elongation
ribosomal large subunit binding
GTPase inhibitor activity
translation repressor activity, mRNA regulatory element binding
ribosomal small subunit binding
cellular response to arsenic-containing substance
regulation of translational elongation
translation factor activity, RNA binding
mRNA 3-UTR AU-rich region binding
regulation of cytoplasmic translation
response to arsenic-containing substance
negative regulation of GTPase activity
ribosome binding
mRNA 3-UTR binding
negative regulation of translation
negative regulation of cellular amide metabolic process
cellular response to insulin stimulus
cellular response to hypoxia
cellular response to decreased oxygen levels
cellular response to oxygen levels
response to insulin
cellular response to oxidative stress
cellular response to peptide hormone stimulus
synapse
neuron projection
cellular response to peptide
response to hypoxia
regulation of translation
response to decreased oxygen levels
response to oxygen levels
translation
response to oxidative stress
response to peptide hormone
regulation of cellular amide metabolic process
peptide biosynthetic process
negative regulation of hydrolase activity