ZNHIT6

Entrez Summary: N/A
UniProt Summary: Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. {ECO:0000269|PubMed:17636026}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 44/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	2/26
breast	3/33
central nervous system	6/56
cervix	1/4
colorectal	1/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	2/21
liver	1/20
lung	4/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	5/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	0/5

Expression Distribution

snoRNA localization
pre-snoRNP complex
box C/D snoRNP assembly
TFIID-class transcription factor complex binding
small nucleolar ribonucleoprotein complex assembly
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of LSU-rRNA
ribosomal large subunit biogenesis
ATPase binding
rRNA processing
RNA localization
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
ribosome biogenesis
enzyme binding
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
protein complex oligomerization
cellular protein-containing complex assembly
RNA processing
identical protein binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression