GUCA1A

Gene Information

Official Symbol: GUCA1A
Official Name: guanylate cyclase activator 1A
Aliases and Previous Symbols: N/A
Entrez ID: 2978
UniProt: P43080
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
UniProt Summary: Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:19459154). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure. {ECO:0000269|PubMed:19459154, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9023
Expression level (log2 read counts): -5.01

Expression Distribution

guanylate cyclase regulator activity
calcium sensitive guanylate cyclase activator activity
positive regulation of guanylate cyclase activity
regulation of guanylate cyclase activity
positive regulation of purine nucleotide biosynthetic process
positive regulation of nucleotide biosynthetic process
positive regulation of cyclase activity
photoreceptor disc membrane
positive regulation of lyase activity
regulation of rhodopsin mediated signaling pathway
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
regulation of cyclase activity
regulation of lyase activity
positive regulation of nucleotide metabolic process
positive regulation of purine nucleotide metabolic process
cellular response to calcium ion
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
positive regulation of small molecule metabolic process
regulation of G protein-coupled receptor signaling pathway
response to calcium ion
cellular response to metal ion
cellular response to inorganic substance
visual perception
sensory perception of light stimulus
response to metal ion
regulation of small molecule metabolic process
response to inorganic substance
calcium ion binding
sensory perception
regulation of response to external stimulus
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
nervous system process
positive regulation of catalytic activity
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of nucleobase-containing compound metabolic process