RPF1

Entrez Summary: N/A
UniProt Summary: May be required for ribosome biogenesis. {ECO:0000269|PubMed:11864606}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trientine 500μM R08 exp534	-2.05
3-Bromopyruvate 7μM R04 exp175	-1.94
CB-5083 0.4μM R08 exp468	-1.85
Mubritinib 0.2μM R02 exp65	-1.84
UMK57 1μM R01 exp59	-1.83
Etoposide 1μM R00 exp19	-1.82
CFI-400945 25μM R08 exp469	-1.81
HMS-I1 1μM R01 exp46	-1.78
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.7
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.75
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.76
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.89
Ibrutinib 1μM R07 exp372	1.89
Daidzin 10μM R06 exp280	1.91

Global Fraction of Cell Lines Where Essential: 139/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	3/28
bone	7/26
breast	1/33
central nervous system	11/56
cervix	1/4
colorectal	7/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	5/21
liver	2/20
lung	14/75
lymphocyte	2/16
ovary	2/26
pancreas	8/24
peripheral nervous system	1/16
plasma cell	4/15
prostate	0/1
skin	5/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	11/22
urinary tract	4/29
uterus	0/5

Expression Distribution

Gene	Correlation
CGB2	0.449
SDE2	0.405

preribosome, large subunit precursor
rRNA binding
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
gene expression