HMS-I1 1μM R01 exp46

Inhibits HDAC

PubChem Name: 2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-6-methylimidazo[1,2-a]pyridine
Synonyms: N/A
CAS #: 702636-92-8
PubChem CID: 2813456
IUPAC: 2-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-methylimidazo[1,2-a]pyridine
INCHI Name: InChI=1S/C16H14N2O2/c1-11-2-5-16-17-13(10-18(16)9-11)12-3-4-14-15(8-12)20-7-6-19-14/h2-5,8-10H,6-7H2,1H3
INCHI Key: ZNAWJWFMKKSTJM-UHFFFAOYSA-N
Molecular Weight: 266.29
Canonical SMILES: CC1=CN2C=C(N=C2C=C1)C3=CC4=C(C=C3)OCCO4
Isomeric SMILES: N/A
Molecular Formula: C16H14N2O2

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
3/3	Scores	View	View	View	View	View

Screen	Correlation	Plot
UMK57 1μM R01 exp59	0.12	View
Vinblastine 0.002μM R01 exp60	0.086	View
Mdivi-1 15μM R05 exp217	0.085	View
Taxol 0.002μM R01 exp54	0.069	View
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	0.059	View
Taxol 0.004μM R03 exp103	0.053	View
Docetaxel 0.002μM R01 exp45	0.091	View
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	0.069	View
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	0.059	View
BML-284 0.09μM R08 exp460	0.058	View
2-Methoxyestradiol 0.55μM R07 exp310	0.056	View
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	0.053	View

GO Term	Fold Change	Genes
regulation of nuclear division	20.82	TRIP13,KNTC1,DRD3,CDC23,PSMA8
cell cycle process	6.14	ASPM,TRIP13,KNTC1,SUGT1,CUL2,MAPRE1,GTSE1,CDC23,TACC3