ATP6V0C
Gene Information
- Official Symbol: ATP6V0C
- Official Name: ATPase H+ transporting V0 subunit c
- Aliases and Previous Symbols: N/A
- Entrez ID: 527
- UniProt: P27449
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Pfam Domains GO Terms
Pfam Domains
| ATP-synt C |
GO Terms
| proton-transporting V-type ATPase, V0 domain |
| proton-transporting ATP synthase activity, rotational mechanism |
| proton-transporting ATPase activity, rotational mechanism |
| phagosome acidification |
| transferrin transport |
| phagosome maturation |
| intracellular pH reduction |
| pH reduction |
| azurophil granule membrane |
| ficolin-1-rich granule membrane |
| iron ion transport |
| phagocytic vesicle membrane |
| tertiary granule membrane |
| regulation of intracellular pH |
| insulin receptor signaling pathway |
| regulation of cellular pH |
| regulation of pH |
| cellular monovalent inorganic cation homeostasis |
| transition metal ion transport |
| monovalent inorganic cation homeostasis |
| proton transmembrane transport |
| cellular response to insulin stimulus |
| regulation of macroautophagy |
| positive regulation of Wnt signaling pathway |
| endosome membrane |
| response to insulin |
| cellular response to peptide hormone stimulus |
| ubiquitin protein ligase binding |
| lysosomal membrane |
| cellular response to peptide |
| regulation of autophagy |
| regulation of Wnt signaling pathway |
| response to peptide hormone |
| monovalent inorganic cation transport |
| focal adhesion |
| response to peptide |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| inorganic cation transmembrane transport |
| myeloid leukocyte activation |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cation transmembrane transport |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| cellular response to nitrogen compound |
| viral process |
| regulated exocytosis |
| cation homeostasis |
| enzyme linked receptor protein signaling pathway |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| leukocyte mediated immunity |
| symbiotic process |
| ion homeostasis |
| exocytosis |
| interspecies interaction between organisms |
| cation transport |
| regulation of cellular catabolic process |
| cellular homeostasis |
| response to hormone |
| leukocyte activation |
| ion transmembrane transport |
| regulation of catabolic process |
| response to organonitrogen compound |
| secretion by cell |
| export from cell |
| cellular response to oxygen-containing compound |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| chemical homeostasis |
| secretion |
| cellular response to endogenous stimulus |
| transmembrane transport |
| ion transport |
| response to endogenous stimulus |
| protein transport |
| peptide transport |
| response to oxygen-containing compound |
| amide transport |
| establishment of protein localization |
| homeostatic process |
| positive regulation of signal transduction |
| positive regulation of cell communication |
| positive regulation of signaling |
| nitrogen compound transport |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nocodazole 0.2μM R00 exp24 | -3.08 |
| Milciclib 2μM R08 exp502 | -2.61 |
| Rotenone 2μM R00 exp33 | -2.61 |
| Etoposide 1μM R00 exp19 | -2.49 |
| Rotenone 20μM R00 exp34 | -2.32 |
| UM0011500 10μM R05 exp246 | -2.29 |
| Bortezomib 0.05μM R00 exp7 | -2.25 |
| CFI-400945 25μM R08 exp469 | -2.18 |
| DABN 20μM R00 exp17 | -2.09 |
| Oligomycin-A 20μM R00 exp26 | -2.01 |
| Vinblastine 0.2μM R03 exp108 | -1.98 |
| Actinomycin-D 0.001μM R00 exp3 | -1.95 |
| BI-2536 0.02μM R03 exp96 | -1.92 |
| RK-33 8μM R08 exp518 | -1.86 |
| PU-H71 1μM R08 exp515 | -1.82 |
| iCRT14 30μM R08 exp492 | -1.79 |
| ABT-702 0.1μM R06 exp260 | -1.78 |
| RO-3307 4.7μM R02 exp80 | -1.78 |
| Doxorubicin 0.02μM R08 exp478 | -1.77 |
| Tozasertib 0.1μM R07 exp414 | -1.75 |
| Mubritinib 0.2μM R02 exp65 | -1.71 |
| VHL-ligand-1 20μM R07 exp421 | 1.74 |
| UM0011500 5μM R05 exp245 | 1.79 |
| Wiskostatin 3μM R07 exp422 | 1.81 |
| ABT-702 5μM R07 exp318 | 1.88 |
| UM131593 0.1μM R01 exp58 | 1.89 |
| Pomalidomide 20μM R07 exp391 | 2.18 |
| HMS-I1 1μM R01 exp46 | 2.44 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| POLR2J3 | 0.644 |
| PSMB4 | 0.555 |
| UPF1 | 0.513 |
| PSMA6 | 0.51 |
| TICRR | 0.501 |
| SLC4A1 | 0.497 |
| PSMB3 | 0.494 |
| SUPT6H | 0.489 |
| TCEB3CL2 | 0.486 |
| PRIM1 | 0.486 |
| TCEB3C | 0.484 |
| AATF | 0.481 |
| CHD4 | 0.478 |
| POLR2J | 0.469 |
| SUPT5H | 0.469 |
| RRP7A | 0.466 |
| PSMD3 | 0.466 |
| KRT78 | 0.466 |
| SLC38A7 | 0.464 |
| RAD51 | 0.462 |
| POLA1 | 0.462 |
| TCEB3CL | 0.457 |
| C1QTNF9B | 0.453 |
| GOLGA6L1 | 0.453 |
| ZNF830 | 0.453 |
| CBWD3 | 0.448 |
| WDR75 | 0.446 |
| NPIPB5 | 0.445 |
| OSBP | 0.444 |
| GOLGA6L3 | 0.444 |
| ISCU | 0.443 |
| COPG1 | 0.443 |
| COL2A1 | 0.442 |
| CLEC11A | 0.441 |
| ARCN1 | 0.441 |
| SLC6A17 | 0.44 |
| PAF1 | 0.439 |
| CDC45 | 0.439 |
| NUP205 | 0.438 |
| TBC1D3H | 0.436 |
| IK | 0.435 |
| NUP153 | 0.435 |
| RPL35 | 0.434 |
| FAM231A | 0.433 |
| CBWD6 | 0.433 |
| FAM231C | 0.433 |
| TBC1D3C | 0.433 |
| TIMELESS | 0.432 |
| VASN | 0.432 |
| COPB1 | 0.43 |
| ORC6 | 0.429 |
| HIST1H2BE | 0.429 |
| RRN3 | 0.428 |
| RPS7 | 0.428 |
| CCNA2 | 0.428 |
| PSMD7 | 0.427 |
| RPS2 | 0.426 |
| AQR | 0.426 |
| EXOSC5 | 0.425 |
| SEMA6B | 0.425 |
| PSMD8 | 0.424 |
| PHF2 | 0.423 |
| POLR1A | 0.423 |
| NPIPB8 | 0.422 |
| CBWD5 | 0.422 |
| TWISTNB | 0.421 |
| IGFN1 | 0.419 |
| TBC1D3F | 0.419 |
| FBXO5 | 0.419 |
| ATP6V0B | 0.418 |
| RIOK2 | 0.418 |
| OGFR | 0.417 |
| VPS52 | 0.416 |
| NUP160 | 0.415 |
| ORC1 | 0.415 |
| CDCA3 | 0.415 |
| POLR2D | 0.413 |
| ANKLE2 | 0.412 |
| UTP3 | 0.41 |
| ATP6V1A | 0.41 |
| PSMB2 | 0.408 |
| LRR1 | 0.408 |
| HINFP | 0.407 |
| TYMS | 0.405 |
| MED14 | 0.405 |
| COPE | 0.405 |
| PSAP | 0.404 |
| TBC1D3G | 0.404 |
| PLK1 | 0.404 |
| NAPA | 0.404 |
| GID4 | 0.404 |
| HIST2H3A | 0.403 |
| HIST2H3C | 0.403 |
| HIST2H2BF | 0.401 |
| SNRNP70 | 0.401 |
| BYSL | 0.4 |
| VPS28 | 0.4 |
| TAF15 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 736/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 33/33 |
| central nervous system | 55/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 74/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 10
- Expression level (log2 read counts): 5.12
Expression Distribution
ATP6V0C Expression in NALM6 Cells: 5.12
