POLR2J

Entrez Summary: N/A
UniProt Summary: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.05μM R00 exp7	-2.2
PU-H71 1μM R08 exp515	-2.18
Mitomycin-C 0.06μM R08 exp503	-2.13
Brefeldin A 0.02μM R00 exp8	-2.07
Rotenone 20μM R00 exp34	-2.01
Pimelic-diphenylamide-106 5μM R00 exp28	-1.98
Etoposide 0.1μM R05 exp198	-1.97
MLN-4924 2μM R00 exp22	-1.94
Vinblastine 0.015μM R05 exp208	-1.9
Rapamycin 2μM R07 exp306	-1.88
Oligomycin-A 20μM R00 exp26	-1.82
Vemurafenib 6.6μM R08 exp434	-1.76
Erlotinib 10μM R05 exp216	-1.74
Nocodazole 0.2μM R00 exp24	-1.72
IWR1 50μM R08 exp495	-1.7
L-BMAA 500 to 750μM on day4 R04 exp185	1.72
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.74
2-Methoxyestradiol 0.55μM R07 exp310	1.78
Docetaxel 0.002μM R01 exp45	1.87
Docosahexaenoic-acid 50μM R07 exp356	1.92
Apcin 25μM plus proTAME 2μM R04 exp177	1.99
Taxol 0.002μM R01 exp54	1.99
Nicotinamide Riboside 100μM R03 exp139	2.12
Ethambutol 25μM R08 exp481	2.31
IU1-C 25μM R04 exp183	2.38
BN82002 4μM R07 exp340	2.62
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	3.14
3-Bromopyruvate 7μM R04 exp175	3.31

Global Fraction of Cell Lines Where Essential: 726/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

LRR domain binding
RNA polymerase II activity
RNA polymerase II, core complex
DNA-directed 5-3 RNA polymerase activity
7-methylguanosine mRNA capping
RNA capping
7-methylguanosine RNA capping
positive regulation of viral transcription
regulation of viral transcription
somatic stem cell population maintenance
snRNA transcription by RNA polymerase II
snRNA transcription
transcription-coupled nucleotide-excision repair
transcription elongation from RNA polymerase II promoter
fibroblast growth factor receptor signaling pathway
regulation of gene silencing by miRNA
regulation of posttranscriptional gene silencing
regulation of gene silencing by RNA
DNA-templated transcription, elongation
ncRNA transcription
positive regulation of viral process
cellular response to fibroblast growth factor stimulus
nucleotide-excision repair
response to fibroblast growth factor
regulation of gene silencing
stem cell population maintenance
maintenance of cell number
protein dimerization activity
transcription initiation from RNA polymerase II promoter
regulation of viral process
DNA-templated transcription, initiation
regulation of symbiosis, encompassing mutualism through parasitism
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
transcription by RNA polymerase II
cellular response to growth factor stimulus
DNA repair