Nicotinamide Riboside 100μM R03 exp139
Mechanism of Action
NAD precursor, activates SIRT1
- Class / Subclass 1: Metabolism / Metabolite
Technical Notes
Compound References
- PubChem Name: Nicotinamide riboside chloride
- Synonyms: N/A
- CAS #: 23111-00-4
- PubChem CID: 90480033
- IUPAC: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;chloride
- INCHI Name: InChI=1S/C11H14N2O5.ClH/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11;/h1-4,7-9,11,14-16H,5H2,(H-,12,17);1H/t7-,8-,9-,11-;/m1./s1
- INCHI Key: YABIFCKURFRPPO-IVOJBTPCSA-N
- Molecular Weight: 290.7
- Canonical SMILES: C1=CC(=C[N+](=C1)C2C(C(C(O2)CO)O)O)C(=O)N.[Cl-]
- Isomeric SMILES: C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N.[Cl-]
- Molecular Formula: C11H15ClN2O5
Compound Supplier
- Supplier Name: BioSynth (Charles Brenner)
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: [M]+ Calcd for C11H15N2O5 255.0975; found 255.0959
- HRMS (ESI-TOF) m/z: [M+H-C5H9O4+]+ Calcd for C6H7N2O 123.0553; found 123.0536
Dose Response Curve
- Platform ID: NICOTINAMIDE-RIBOSE
- Min: -3.4168; Max: 11.4802
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 100µM
- Days of incubation: 8
- Doublings: 7.9
- Numbers of reads: 11225449
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Nicotinamide Riboside 100μM R03 exp139
Dihydrosphingosine 8μM R08 exp476 vs Nicotinamide Riboside 100μM R03 exp139
