TONSL

Entrez Summary: N/A
UniProt Summary: Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:7738005}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CyclicAMP 200μM R08 exp475	1.7
BH1 1μM R04 exp169	1.73
Ethanol 0.003 R08 exp437	1.75
Nicotinamide Riboside 100μM R03 exp139	1.9
Deguelin 0.05μM R02 exp69	2.13

Global Fraction of Cell Lines Where Essential: 700/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	26/28
bone	25/25
breast	30/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	15/15
kidney	20/21
liver	20/20
lung	73/75
lymphocyte	14/14
ovary	24/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	13/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	20/22
urinary tract	27/29
uterus	5/5

Expression Distribution

Ank
Ank 2

FACT complex
nuclear replication fork
MCM complex
DNA replication factor A complex
cytoplasmic sequestering of transcription factor
cytoplasmic sequestering of protein
replication fork processing
DNA-dependent DNA replication maintenance of fidelity
double-strand break repair via homologous recombination
recombinational repair
maintenance of protein location
DNA-dependent DNA replication
histone binding
negative regulation of DNA-binding transcription factor activity
maintenance of location
double-strand break repair
DNA replication
DNA recombination
transcription corepressor activity
nuclear body
regulation of DNA-binding transcription factor activity
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
negative regulation of molecular function
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process