BH1 1μM R04 exp169

Unknown

PubChem Name: 4-Amino-N-[4-[5-[(4-aminobenzoyl)amino]-4-chloro-1H-benzimidazol-2-yl]-2-chlorophenyl]benzamide
Synonyms: N/A
CAS #: 331424-77-2
PubChem CID: 4225810
IUPAC: 4-amino-N-[4-[5-[(4-aminobenzoyl)amino]-4-chloro-1H-benzimidazol-2-yl]-2-chlorophenyl]benzamide
INCHI Name: InChI=1S/C27H20Cl2N6O2/c28-19-13-16(5-10-20(19)33-26(36)14-1-6-17(30)7-2-14)25-32-22-12-11-21(23(29)24(22)35-25)34-27(37)15-3-8-18(31)9-4-15/h1-13H,30-31H2,(H,32,35)(H,33,36)(H,34,37)
INCHI Key: TYLWSXFXCJNMCK-UHFFFAOYSA-N
Molecular Weight: 531.4
Canonical SMILES: C1=CC(=CC=C1C(=O)NC2=C(C=C(C=C2)C3=NC4=C(N3)C=CC(=C4Cl)NC(=O)C5=CC=C(C=C5)N)Cl)N
Isomeric SMILES: N/A
Molecular Formula: C27H20Cl2N6O2

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C27H20Cl2N6O2 531.10976; found 531.11054

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
54/0	Scores	View	View	View	View	View

GO Term	Fold Change	Genes
sphinganine metabolic process	571.52	SPTLC1,SPTLC2
sphingomyelin biosynthetic process	228.61	SPTLC1,SGMS1,SPTLC2,OSBP
Golgi transport complex	214.32	COG5,COG7,COG6
retrograde transport, vesicle recycling within Golgi	214.32	COG5,COG7,COG6
sphingomyelin metabolic process	127.00	SPTLC1,SGMS1,SPTLC2,OSBP
sphingoid metabolic process	85.73	KDSR,SPTLC1,SPTLC2
intracellular cholesterol transport	71.44	LDLR,LDLRAP1,OSBP
regulation of cholesterol metabolic process	67.24	SCAP,LDLR,LDLRAP1,MBTPS1
intracellular sterol transport	61.23	LDLR,LDLRAP1,OSBP
intracellular lipid transport	54.43	CERT1,LDLR,LDLRAP1,OSBP
sphingolipid biosynthetic process	28.29	KDSR,SPTLC1,SGMS1,SPTLC2,OSBP
sphingolipid metabolic process	22.12	KDSR,SPTLC1,SGMS1,CERT1,SPTLC2,OSBP
Golgi organization	21.49	ARL1,COG5,DYM,COG7,COG6
membrane lipid biosynthetic process	20.41	KDSR,SPTLC1,SGMS1,SPTLC2,OSBP
membrane lipid metabolic process	16.98	KDSR,SPTLC1,SGMS1,CERT1,SPTLC2,OSBP
Golgi apparatus subcompartment	12.56	SGMS1,ARL1,COG5,COG7,TBC1D23,MBTPS1,OSBP,COG6
alcohol metabolic process	10.82	SCAP,SPTLC1,LDLR,LDLRAP1,MBTPS1,SPTLC2
Golgi membrane	8.71	SCAP,SGMS1,ARL1,COG5,ATP6V0A2,UNC50,COG7,MBTPS1,OSBP,COG6
organic hydroxy compound metabolic process	8.46	SCAP,SPTLC1,LDLR,LDLRAP1,MBTPS1,SPTLC2,OSBP

GO Term	Fold Change	Genes
nuclear pore outer ring	207.18	NUP98,NUP43,SEC13
COPII-coated vesicle cargo loading	118.39	SEC24C,SEC23B,SEC31A
COPII vesicle coat	110.49	SEC24C,SEC23B,SEC13
structural constituent of nuclear pore	72.06	NUP93,NUP98,NUP188
vesicle cargo loading	71.29	SEC24C,SEC23B,SEC13,SEC31A
COPII-coated vesicle budding	58.15	SEC24C,SEC23B,SEC13,SEC31A
ER to Golgi transport vesicle membrane	37.46	SEC24C,SEC23B,SEC13,SEC31A
nuclear pore	30.03	NUP93,NUP98,NUP43,SEC13,NUP188
vesicle budding from membrane	29.86	SEC24C,SEC23B,SEC13,SEC31A
mRNA transport	24.23	NUP93,NUP98,NUP43,SEC13,NUP188
RNA transport	19.59	NUP93,NUP98,NUP43,SEC13,NUP188
nucleic acid transport	19.59	NUP93,NUP98,NUP43,SEC13,NUP188
establishment of RNA localization	19.32	NUP93,NUP98,NUP43,SEC13,NUP188
protein localization to nucleus	18.11	NUP93,MDM2,RRP7A,NUP98,SEC13,NUP188
nucleobase-containing compound transport	16.09	SLC28A3,NUP93,NUP98,NUP43,SEC13,NUP188
transport vesicle membrane	14.67	BCL2L1,SEC24C,SEC23B,SEC13,ATP6AP1,SEC31A
nucleocytoplasmic transport	14.17	NUP93,NUP98,DUSP16,NUP43,SEC13,NUP188
nuclear transport	14.17	NUP93,NUP98,DUSP16,NUP43,SEC13,NUP188
intracellular protein transport	8.16	SYVN1,SEC24C,NUP93,DUSP16,SEC23B,USP9X,SEC13,NUP188,ATP6AP1,SEC31A