VKORC1L1
Gene Information
- Official Symbol: VKORC1L1
- Official Name: vitamin K epoxide reductase complex subunit 1 like 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 154807
- UniProt: Q8N0U8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016].
- UniProt Summary: Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:23928358, ECO:0000269|PubMed:24532791}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18545
- Expression level (log2 read counts): 6.61
VKORC1L1 Expression in NALM6 Cells: 6.61
