DMXL1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bafilomycin-A1 0.009μM R08 exp454	-3.28
Vemurafenib 6.6μM R08 exp434	-2.78
Vemurafenib 6.6μM R02 exp89	-2.73
Clomiphene 4.4μM R02 exp68	-2.62
BH1 1μM R04 exp169	-2.45
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.39
Cryptotanshinone 12μM R05 exp227	-2.19
Q15 2.7μM R02 exp79	-1.88
Cannabidiol 20μM R08 exp466	-1.77

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rav1p C
WD40

RAVE complex
vacuolar acidification
intracellular pH reduction
pH reduction
regulation of intracellular pH
regulation of cellular pH
regulation of pH
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
chemical homeostasis
homeostatic process