DMXL1 [The Human Chemical-Genetic Interaction Map Project]

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======= DMXL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DMXL1
  * **<color #00a2e8>Official Name</color>**: Dmx like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1657|1657]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y485|Q9Y485]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DMXL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DMXL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605671|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rav1p C|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RAVE complex|
|vacuolar acidification|
|intracellular pH reduction|
|pH reduction|
|regulation of intracellular pH|
|regulation of cellular pH|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|monovalent inorganic cation homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|chemical homeostasis|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-3.28|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.78|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.73|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.62|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.45|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.39|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.19|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.88|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.42|
|[[:human genes:c:chka|CHKA]]|0.411|
|[[:human genes:c:cog5|COG5]]|0.407|
|[[:human genes:c:cog7|COG7]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14177
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DMXL1 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>