CNEP1R1

Entrez Summary: N/A
UniProt Summary: Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. {ECO:0000269|PubMed:22134922}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BH1 1μM R04 exp169	-2.6
Q15 1 to 2μM on day4 R04 exp164	-2.23
Vemurafenib 6.6μM R08 exp434	-2.2
LY2090314 0.003μM R08 exp500 no dilution day6	-2.16
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.02
LY2090314 0.003μM R08 exp499	-1.99
CFI-400945 25μM R08 exp469	-1.97
Tubacin 1.6μM R07 exp416	-1.88
Q15 2.7μM R02 exp79	-1.72
MS023 2μM R03 exp134	1.8
Monensin 0.3μM R08 exp507	1.85
5-Fluorouracil 20μM R00 exp2	1.96

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Nem1-Spo7 phosphatase complex
mitotic nuclear envelope disassembly
positive regulation of triglyceride biosynthetic process
membrane disassembly
nuclear envelope disassembly
regulation of triglyceride biosynthetic process
positive regulation of triglyceride metabolic process
regulation of triglyceride metabolic process
positive regulation of protein dephosphorylation
nuclear envelope organization
positive regulation of dephosphorylation
positive regulation of lipid biosynthetic process
nucleus organization
regulation of protein dephosphorylation
positive regulation of lipid metabolic process
protein localization to nucleus
nuclear envelope
regulation of lipid biosynthetic process
regulation of dephosphorylation
nuclear membrane
regulation of lipid metabolic process
cellular component disassembly
endomembrane system organization
mitotic cell cycle process
mitotic cell cycle
protein localization to organelle
membrane organization
cell cycle process
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
lipid metabolic process
positive regulation of protein modification process
cell cycle
cellular protein localization
cellular macromolecule localization
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process