MMD

Entrez Summary: N/A
UniProt Summary: Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cytolysis
late endosome membrane
signaling receptor activity
protein kinase activity
lysosomal membrane
positive regulation of neuron differentiation
positive regulation of neurogenesis
positive regulation of protein kinase activity
positive regulation of nervous system development
positive regulation of cell development
positive regulation of kinase activity
regulation of neuron differentiation
positive regulation of transferase activity
regulation of protein kinase activity
regulation of neurogenesis
regulation of kinase activity
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
protein phosphorylation
regulation of transferase activity
Golgi apparatus
positive regulation of protein phosphorylation
regulation of protein localization
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
phosphorylation
positive regulation of developmental process
integral component of plasma membrane
positive regulation of catalytic activity
regulation of protein phosphorylation
generation of neurons
regulation of phosphorylation
positive regulation of cellular protein metabolic process
neurogenesis
positive regulation of protein metabolic process
positive regulation of multicellular organismal process
positive regulation of molecular function