MMD [The Human Chemical-Genetic Interaction Map Project]

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======= MMD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MMD
  * **<color #00a2e8>Official Name</color>**: monocyte to macrophage differentiation associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23531|23531]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15546|Q15546]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MMD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MMD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604467|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HlyIII|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytolysis|
|late endosome membrane|
|signaling receptor activity|
|protein kinase activity|
|lysosomal membrane|
|positive regulation of neuron differentiation|
|positive regulation of neurogenesis|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of kinase activity|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of kinase activity|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|Golgi apparatus|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.31|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-3.03|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.69|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.3|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.3|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.24|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.13|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.7|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.78|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.82|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:acsl4|ACSL4]]|0.512|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.495|
|[[:human genes:c:chka|CHKA]]|0.467|
|[[:human genes:a:arpc4|ARPC4]]|0.448|
|[[:human genes:p:pik3cd|PIK3CD]]|0.433|
|[[:human genes:i:igll1|IGLL1]]|0.433|
|[[:human genes:a:arpc2|ARPC2]]|0.41|
|[[:human genes:e:ergic1|ERGIC1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6352
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MMD Expression in NALM6 Cells: 3.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>