ARPC2
Gene Information
- Official Symbol: ARPC2
- Official Name: actin related protein 2/3 complex subunit 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10109
- UniProt: O15144
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
Pfam Domains GO Terms
Pfam Domains
| P34-Arc |
GO Terms
| muscle cell projection membrane |
| actin polymerization-dependent cell motility |
| Arp2/3 protein complex |
| positive regulation of lamellipodium assembly |
| Arp2/3 complex-mediated actin nucleation |
| positive regulation of lamellipodium organization |
| regulation of lamellipodium assembly |
| actin filament polymerization |
| actin nucleation |
| positive regulation of substrate adhesion-dependent cell spreading |
| regulation of lamellipodium organization |
| actin polymerization or depolymerization |
| regulation of substrate adhesion-dependent cell spreading |
| site of double-strand break |
| protein polymerization |
| ephrin receptor signaling pathway |
| positive regulation of actin filament polymerization |
| positive regulation of plasma membrane bounded cell projection assembly |
| structural constituent of cytoskeleton |
| positive regulation of cell-substrate adhesion |
| positive regulation of protein polymerization |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| positive regulation of cell morphogenesis involved in differentiation |
| regulation of actin filament polymerization |
| lamellipodium |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| actin filament binding |
| regulation of cell-substrate adhesion |
| actin cytoskeleton |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| actin filament organization |
| Fc receptor signaling pathway |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| endosome |
| regulation of cell morphogenesis involved in differentiation |
| neuron projection |
| phagocytosis |
| regulation of actin cytoskeleton organization |
| glutamatergic synapse |
| regulation of supramolecular fiber organization |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| positive regulation of cell adhesion |
| focal adhesion |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| immune response-activating signal transduction |
| actin filament-based process |
| immune response-regulating signaling pathway |
| positive regulation of organelle organization |
| activation of immune response |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| cellular protein-containing complex assembly |
| membrane organization |
| positive regulation of immune response |
| regulation of cell development |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| immune effector process |
| cytoskeleton organization |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| locomotion |
| positive regulation of developmental process |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| regulation of immune system process |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 4369
- Expression level (log2 read counts): 7.68
Expression Distribution
ARPC2 Expression in NALM6 Cells: 7.68
