COMMD5

Entrez Summary: N/A
UniProt Summary: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966). {ECO:0000250|UniProtKB:Q9ERR2, ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.89
Vemurafenib 6.6μM R08 exp434	-2.83
Q15 2.7μM R02 exp79	-2.76
Clomiphene 4.4μM R02 exp68	-2.57
FTY720 3μM R08 exp483	-2.55
Senexin-A 25μM R07 exp400	-2.55
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.3
Bafilomycin-A1 0.009μM R08 exp454	-2.27
Vemurafenib 6.6μM R02 exp89	-2.27
Cryptotanshinone 12μM R05 exp227	-2.23
Hydroxychloroquine 30μM R08 exp490	-2.23
Q15 1 to 2μM on day4 R04 exp164	-2.01
Chloroquine 32μM R08 exp470	-1.98
ZLN024 50μM R08 exp538	-1.86
LJH685 50μM R08 exp433	-1.82
Thioridazine 5μM R08 exp530	-1.78
EPZ-5676 30μM R05 exp233	-1.77
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.76
IU1-C 25μM R04 exp183	-1.73

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution