ACTR3
Gene Information
- Official Symbol: ACTR3
- Official Name: actin related protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 10096
- UniProt: P61158
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. {ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:9000076}.
Pfam Domains GO Terms
Pfam Domains
| Actin |
GO Terms
| meiotic chromosome movement towards spindle pole |
| chromosome movement towards spindle pole |
| actin polymerization-dependent cell motility |
| meiotic cytokinesis |
| Arp2/3 protein complex |
| actin cortical patch |
| asymmetric cell division |
| Arp2/3 complex-mediated actin nucleation |
| actin nucleation |
| spindle localization |
| brush border |
| site of double-strand break |
| establishment of chromosome localization |
| chromosome localization |
| ephrin receptor signaling pathway |
| meiotic chromosome segregation |
| positive regulation of actin filament polymerization |
| cytoskeleton-dependent cytokinesis |
| cytokinesis |
| structural constituent of cytoskeleton |
| positive regulation of protein polymerization |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| meiotic nuclear division |
| cellular response to interferon-gamma |
| regulation of actin filament polymerization |
| meiotic cell cycle process |
| cell-cell junction |
| lamellipodium |
| response to interferon-gamma |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| actin filament binding |
| actin cytoskeleton |
| nuclear chromosome segregation |
| positive regulation of cytoskeleton organization |
| meiotic cell cycle |
| regulation of protein polymerization |
| actin filament organization |
| Fc receptor signaling pathway |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| microtubule-based movement |
| chromosome segregation |
| nuclear division |
| organelle fission |
| phagocytosis |
| regulation of actin cytoskeleton organization |
| cilium assembly |
| regulation of supramolecular fiber organization |
| establishment of organelle localization |
| cilium organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| focal adhesion |
| plasma membrane bounded cell projection assembly |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| cell projection assembly |
| immune response-regulating cell surface receptor signaling pathway |
| cell division |
| actin cytoskeleton organization |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| immune response-activating signal transduction |
| actin filament-based process |
| organelle localization |
| immune response-regulating signaling pathway |
| positive regulation of organelle organization |
| activation of immune response |
| microtubule-based process |
| enzyme linked receptor protein signaling pathway |
| organelle assembly |
| innate immune response |
| membrane organization |
| positive regulation of immune response |
| defense response to other organism |
| regulation of cellular component biogenesis |
| cell cycle process |
| cellular response to cytokine stimulus |
| cell motility |
| localization of cell |
| immune effector process |
| response to cytokine |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| defense response |
| cell cycle |
| reproductive process |
| reproduction |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of RNA metabolic process |
| establishment of localization in cell |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 4/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 1/9 |
| thyroid | 1/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2936
- Expression level (log2 read counts): 7.51
Expression Distribution
ACTR3 Expression in NALM6 Cells: 7.51
