Epothilone-B 0.0015μM R05 exp231
Mechanism of Action
Inhibits microtubule depolymerization, parent compound of ixabepilone
- Class / Subclass 1: Cell Cycle / Microtubule Poison
- Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor
Technical Notes
Compound References
- PubChem Name: Epothilone B
- Synonyms: EPO 906; Patupilone
- CAS #: 152044-54-7
- PubChem CID: 448013
- IUPAC: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
- INCHI Name: InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
- INCHI Key: QXRSDHAAWVKZLJ-PVYNADRNSA-N
- Molecular Weight: 507.7
- Canonical SMILES: CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C
- Isomeric SMILES: C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C
- Molecular Formula: C27H41NO6S
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: E2656
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C27H41NO6S 508.27274; found 508.27356
Dose Response Curve
- Platform ID: Epithilone-B
- Min: -7.4834; Max: 85.8439
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.0010 |
| IC30 | 0.0014 |
| IC40 | 0.0019 |
| IC50 | 0.0025 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 05
- Dose: 1.5nM
- Days of incubation: 8
- Doublings: 4.8
- Numbers of reads: 20868466
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 14/10 | Scores |
Epothilone-B 0.0015μM R05 exp231
Epothilone-B 0.0015μM R05 exp231 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Epothilone-B 0.0015μM R05 exp231 vs Taxol 0.004μM R03 exp103
Epothilone-B 0.0015μM R05 exp231 vs Epothilone-D 0.004 to 0.006μM on day4 R05 exp232
Epothilone-B 0.0015μM R05 exp231 vs Mdivi-1 15μM R05 exp217
Epothilone-B 0.0015μM R05 exp231 vs Quercetin 20μM R08 exp517
Epothilone-B 0.0015μM R05 exp231 vs Vincristine 0.0005μM R04 exp190
Epothilone-B 0.0015μM R05 exp231 vs UMK57 0.6μM R03 exp107
Epothilone-B 0.0015μM R05 exp231 vs S-trityl-L-cysteine 0.5μM R05 exp243
Epothilone-B 0.0015μM R05 exp231 vs LY2090314 0.003μM R08 exp500 no dilution day6
Epothilone-B 0.0015μM R05 exp231 vs UMK57 1μM R01 exp59
Epothilone-B 0.0015μM R05 exp231 vs Genistein 15μM R07 exp360
Cabazitaxel 0.001μM R05 exp223 vs Epothilone-B 0.0015μM R05 exp231
Docetaxel 0.002μM R01 exp45 vs Epothilone-B 0.0015μM R05 exp231
Docetaxel 0.001 to 0.002μM on day4 R04 exp159 vs Epothilone-B 0.0015μM R05 exp231
BML-284 0.09μM R08 exp460 vs Epothilone-B 0.0015μM R05 exp231
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Epothilone-B 0.0015μM R05 exp231
Colchicine 0.009μM R05 exp215 vs Epothilone-B 0.0015μM R05 exp231
Demecolcine 0.03μM R05 exp228 vs Epothilone-B 0.0015μM R05 exp231
