ATP1A1
Gene Information
- Official Symbol: ATP1A1
- Official Name: ATPase Na+/K+ transporting subunit alpha 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 476
- UniProt: P05023
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Hydrolase |
| Cation ATPase C |
| HAD |
| E1-E2 ATPase |
| Cation ATPase N |
GO Terms
| response to glycoside |
| negative regulation of glucocorticoid metabolic process |
| negative regulation of glucocorticoid biosynthetic process |
| negative regulation of steroid hormone biosynthetic process |
| steroid hormone binding |
| regulation of glucocorticoid biosynthetic process |
| sodium ion binding |
| regulation of glucocorticoid metabolic process |
| membrane hyperpolarization |
| negative regulation of hormone biosynthetic process |
| regulation of steroid hormone biosynthetic process |
| sodium:potassium-exchanging ATPase activity |
| negative regulation of hormone metabolic process |
| potassium ion binding |
| sodium:potassium-exchanging ATPase complex |
| relaxation of cardiac muscle |
| cellular potassium ion homeostasis |
| sodium ion export across plasma membrane |
| positive regulation of striated muscle contraction |
| establishment or maintenance of transmembrane electrochemical gradient |
| cell communication by electrical coupling involved in cardiac conduction |
| cellular sodium ion homeostasis |
| membrane repolarization during action potential |
| membrane repolarization during cardiac muscle cell action potential |
| cardiac muscle cell membrane repolarization |
| cell communication by electrical coupling |
| ankyrin binding |
| relaxation of muscle |
| phosphatidylinositol 3-kinase binding |
| membrane repolarization |
| negative regulation of steroid biosynthetic process |
| negative regulation of heart contraction |
| negative regulation of steroid metabolic process |
| regulation of the force of heart contraction |
| regulation of hormone biosynthetic process |
| potassium ion homeostasis |
| negative regulation of blood circulation |
| sodium ion homeostasis |
| ADP binding |
| regulation of cardiac muscle cell contraction |
| regulation of hormone metabolic process |
| positive regulation of heart contraction |
| export across plasma membrane |
| cardiac muscle cell action potential involved in contraction |
| regulation of actin filament-based movement |
| cardiac muscle cell contraction |
| T-tubule |
| potassium ion import across plasma membrane |
| cell communication involved in cardiac conduction |
| positive regulation of muscle contraction |
| intercalated disc |
| phosphatase activity |
| negative regulation of lipid biosynthetic process |
| cardiac muscle cell action potential |
| extracellular vesicle |
| regulation of cardiac conduction |
| positive regulation of blood circulation |
| caveola |
| inorganic ion import across plasma membrane |
| inorganic cation import across plasma membrane |
| regulation of cardiac muscle contraction |
| cardiac muscle contraction |
| cellular response to mechanical stimulus |
| negative regulation of lipid metabolic process |
| regulation of sodium ion transport |
| heart contraction |
| regulation of steroid biosynthetic process |
| actin-mediated cell contraction |
| sodium ion transmembrane transport |
| regulation of striated muscle contraction |
| cardiac conduction |
| action potential |
| import across plasma membrane |
| sarcolemma |
| heart process |
| melanosome |
| chaperone binding |
| striated muscle contraction |
| cellular monovalent inorganic cation homeostasis |
| actin filament-based movement |
| regulation of steroid metabolic process |
| multicellular organismal signaling |
| monovalent inorganic cation homeostasis |
| proton transmembrane transport |
| sodium ion transport |
| potassium ion transmembrane transport |
| regulation of muscle contraction |
| potassium ion transport |
| regulation of blood pressure |
| regulation of lipid biosynthetic process |
| cellular response to steroid hormone stimulus |
| basolateral plasma membrane |
| response to mechanical stimulus |
| regulation of muscle system process |
| regulation of heart contraction |
| protein domain specific binding |
| muscle contraction |
| postsynaptic density |
| endosome |
| regulation of blood circulation |
| muscle system process |
| dephosphorylation |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| apical plasma membrane |
| response to steroid hormone |
| cellular response to external stimulus |
| regulation of metal ion transport |
| regulation of actin filament-based process |
| blood circulation |
| regulation of lipid metabolic process |
| circulatory system process |
| monovalent inorganic cation transport |
| regulation of membrane potential |
| protein kinase binding |
| cellular response to lipid |
| regulation of hormone levels |
| cellular response to organic cyclic compound |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| actin filament-based process |
| regulation of system process |
| protein-containing complex |
| cellular response to hormone stimulus |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| import into cell |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| response to lipid |
| cellular homeostasis |
| response to hormone |
| response to organic cyclic compound |
| ion transmembrane transport |
| Golgi apparatus |
| regulation of cellular component movement |
| endoplasmic reticulum |
| response to drug |
| export from cell |
| chemical homeostasis |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| transmembrane transport |
| ion transport |
| response to endogenous stimulus |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| homeostatic process |
| positive regulation of multicellular organismal process |
| regulation of transport |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 602/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 25/28 |
| blood | 25/28 |
| bone | 16/26 |
| breast | 31/33 |
| central nervous system | 33/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 11/13 |
| fibroblast | 0/1 |
| gastric | 14/16 |
| kidney | 18/21 |
| liver | 16/20 |
| lung | 59/75 |
| lymphocyte | 15/16 |
| ovary | 22/26 |
| pancreas | 24/24 |
| peripheral nervous system | 4/16 |
| plasma cell | 13/15 |
| prostate | 0/1 |
| skin | 21/24 |
| soft tissue | 8/9 |
| thyroid | 1/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 25/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 1470
- Expression level (log2 read counts): 9.41
Expression Distribution
ATP1A1 Expression in NALM6 Cells: 9.41
