ATAT1

Entrez Summary: N/A
UniProt Summary: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:24097348, ECO:0000269|PubMed:24906155}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R01 exp48	1.72
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.98
Vincristine 0.0005μM R04 exp190	2.1
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.27
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	2.99
Mdivi-1 15μM R05 exp217	3.09
BML-284 0.09μM R08 exp460	3.5
Demecolcine 0.03μM R05 exp228	4.1
Vinblastine 0.002μM R01 exp60	4.4
Colchicine 0.009μM R05 exp215	4.7
UMK57 1μM R01 exp59	5.14
UM131593 0.2μM R03 exp106	6.67

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tubulin N-acetyltransferase activity
alpha-tubulin acetylation
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
microtubule bundle
positive regulation of NLRP3 inflammasome complex assembly
coenzyme binding
regulation of NLRP3 inflammasome complex assembly
dentate gyrus development
clathrin-coated pit
mitotic spindle
hippocampus development
limbic system development
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
regulation of fat cell differentiation
internal protein amino acid acetylation
protein acetylation
pallium development
protein acylation
regulation of microtubule cytoskeleton organization
regulation of microtubule-based process
positive regulation of protein complex assembly
telencephalon development
axon
peptidyl-lysine modification
microtubule
cilium assembly
cilium organization
forebrain development
focal adhesion
plasma membrane bounded cell projection assembly
regulation of protein complex assembly
cell projection assembly
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
spermatogenesis
male gamete generation
gamete generation
brain development
organelle assembly