KIF2A

Entrez Summary: The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cabazitaxel 0.001μM R05 exp223	-4.04
Docetaxel 0.002μM R01 exp45	-3.4
Taxol 0.004μM R03 exp103	-3.27
Epothilone-B 0.0015μM R05 exp231	-3.24
Taxol 0.002μM R01 exp54	-3.22
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.89
Vinblastine 0.002μM R01 exp60	-2.35
CCT251545 0.2μM R06 exp271	-2.21
D-Fructose 10000μM R06 exp279	-2.09
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.06
NFN1 0.1μM R01 exp49	-2.05
Dihydrosphingosine 8μM R08 exp476	-2.01
Vincristine 0.0005μM R04 exp190	-1.98
Etoposide 0.1μM R05 exp198	-1.94
Adefovir 20μM R07 exp332	-1.94
HMS-I2 5μM R06 exp287	-1.91
FBS-Wisent 0.1 R07 exp426	-1.86
Curcumin 6.5μM R06 exp277	-1.85
Vinorelbine 0.001μM R05 exp249	-1.82
BML-284 0.09μM R08 exp460	-1.81
YM155 0.0002μM R01 exp61	-1.81
BN82002 4μM R07 exp340	-1.74
Metformin 100 to 150μM on day4 R04 exp170	-1.73
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.71
MK2206 4μM R08 exp504	1.89
BI-D1870 2μM R04 exp162	2.01
BI-6727 0.0125μM R03 exp97	2.08
MS023 7μM R03 exp135	2.15
HMS-I1 1μM R01 exp46	2.22
ONC212 0.15μM R08 exp513	2.6
Mdivi-1 15μM R05 exp217	3.25
UMK57 1μM R01 exp59	3.41

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

centriolar subdistal appendage
microtubule depolymerization
sperm principal piece
protein depolymerization
mitotic spindle assembly
spindle microtubule
motor activity
microtubule polymerization or depolymerization
kinesin complex
microtubule motor activity
mitotic spindle organization
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
spindle assembly
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
microtubule cytoskeleton organization involved in mitosis
spindle pole
cellular protein complex disassembly
centriole
mitotic nuclear division
spindle organization
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
ATPase activity
microtubule binding
protein-containing complex disassembly
microtubule-based movement
nuclear body
nuclear division
organelle fission
microtubule
Golgi vesicle transport
cellular component disassembly
supramolecular fiber organization
microtubule cytoskeleton organization
centrosome
cell division