TCF4

Gene Information

Official Symbol: TCF4
Official Name: transcription factor 4
Aliases and Previous Symbols: N/A
Entrez ID: 6925
UniProt: P15884
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-4.49
Ibrutinib 10μM R08 exp442	-4.31
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-4.31
Milciclib 2μM R08 exp502	-4.18
THZ531 0.11 to 0.175μM on day4 R07 exp413	-4.12
BI-D1870 2μM R04 exp162	-3.97
Mdivi-1 15μM R05 exp217	-3.88
All-trans-Retinoic-Acid 40μM R07 exp334	-3.86
UNC1999 2μM R03 exp155	-3.82
Colchicine 0.009μM R05 exp215	-3.78
UM0129480 7μM R02 exp85	-3.78
THZ531 0.225μM R08 exp444	-3.77
Citral 50μM R06 exp274	-3.76
Sulforaphane 9μM R08 exp526 no dilution day6	-3.72
I-BRD9 4μM R07 exp365	-3.66
THZ531 0.11μM R07 exp409	-3.66
CAY10603 0.55μM R08 exp467	-3.62
Demecolcine 0.03μM R05 exp228	-3.58
Trichostatin-A 0.06μM R07 exp415	-3.56
LY2090314 0.003μM R08 exp500 no dilution day6	-3.54
THZ531 0.11 to 0.125μM on day4 R07 exp410	-3.53
NN-Dimethylsphingosine 2.5μM R08 exp508	-3.49
GSK626616 14μM R08 exp485	-3.48
Azithromycin 100μM R08 exp452	-3.45
BML-284 0.09μM R08 exp460	-3.42
Trimetrexate 0.03μM R08 exp535	-3.41
Wortmannin 5μM R00 exp38	-3.37
GSK343 3μM R03 exp124	-3.35
Radicicol 0.16μM R05 exp242	-3.33
Citral 75μM R06 exp275	-3.32
FTY720 3μM R08 exp483	-3.3
EPZ-5676 30μM R05 exp233	-3.27
Pterostilbene 16μM R02 exp78	-3.27
YM155 0.001μM R08 exp432	-3.27
ETC-159 50μM R08 exp480	-3.24
LY2090314 0.003μM R08 exp499	-3.21
FK-506 30μM R07 exp359	-3.2
Vincristine 0.0005μM R04 exp190	-3.19
Hippuristanol 0.12μM R08 exp488	-3.11
MK2206 4μM R08 exp504	-3.07
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-3.06
Genistein 15μM R07 exp360	-3.02
Momordin-Ic 10μM R08 exp506	-3.01
Lead acetate 2000μM R08 exp498 no dilution day6	-3
Chlorpromazine 10μM R07 exp344	-2.98
Quercetin 20μM R08 exp517	-2.98
Thapsigargin 0.005μM R07 exp407	-2.98
Tubastatin-A 2.5μM R07 exp417	-2.97
Cyclosporin-A 0.8μM R07 exp347	-2.92
Nifuroxazide 5μM R03 exp102	-2.92
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.9
Nutlin-3A 1.6μM R06 exp294	-2.9
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.9
Lead acetate 2000μM R08 exp497	-2.89
Fluvastatin 2.2μM R06 exp282	-2.86
Wortmannin 0.5μM R00 exp37	-2.86
Epothilone-B 0.0015μM R05 exp231	-2.81
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.8
Dimethyloxaloylglycine 100μM R05 exp229	-2.79
iCRT14 30μM R08 exp492	-2.77
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.71
Arsenate 40μM R06 exp264	-2.71
WYE-354 6μM R02 exp90	-2.71
Amiloride 100μM R08 exp447	-2.7
Erlotinib 10μM R05 exp216	-2.69
Dorsomorphin 5μM R07 exp357	-2.65
Adefovir 20μM R07 exp332	-2.64
Dimethyl-Sulfoxide 1pc R03 exp120	-2.62
Quinacrine 2.5μM R03 exp146	-2.62
Cannabidiol 20μM R08 exp466	-2.61
Clomiphene 4.4μM R02 exp68	-2.61
CoCl2 18μM R07 exp346	-2.6
Actinomycin-D 0.001μM R00 exp3	-2.59
Rapamycin 2μM R07 exp306	-2.59
Apcin 25μM plus proTAME 2μM R04 exp177	-2.58
Sulforaphane 9μM R08 exp525	-2.57
Rapamycin 10μM R00 exp30	-2.56
Ribavirin 10 to 15μM on day4 R04 exp160	-2.56
BVD-523 15μM R02 exp67	-2.54
Menadione 5μM R06 exp292	-2.54
UMK57 1μM R01 exp59	-2.54
FK-506 5μM R07 exp358	-2.52
Metformin 100 to 150μM on day4 R04 exp170	-2.51
Bisphenol A 100μM R06 exp269	-2.48
Taxol 0.004μM R03 exp103	-2.47
ZLN024 50μM R08 exp538	-2.47
NFN1 1μM R03 exp100	-2.45
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.43
Diepoxybutane 3μM R07 exp354	-2.43
Lead acetate 990μM R08 exp496	-2.43
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.42
AICAR 240μM R03 exp116	-2.41
Alpha-Amanitin 0.5μM R00 exp5	-2.4
Vinblastine 0.002μM R01 exp60	-2.4
proTAME 5μM R04 exp187	-2.39
Rucaparib 6.5μM R08 exp520	-2.37
Talazoparib 0.006μM R06 exp299	-2.37
HMS-I1 1μM R01 exp46	-2.34
LJH685 50μM R08 exp433	-2.33
GSK-J4 1-1.25μM to day4 R07 exp363	-2.31
UM0130462 0.025 to 0.035μM day4 R05 exp247	-2.31
GSK-J4 1μM R07 exp362	-2.3
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.29
5-Fluorouracil 2μM R00 exp1	-2.28
Rapamycin 0.001μM R08 exp429	-2.25
Chloroquine 32μM R08 exp470	-2.23
RO-3307 4.7μM R02 exp80	-2.21
Calcium Ionophore 0.4μM R07 exp342	-2.2
Golgicide-A 4μM R03 exp122	-2.2
Resveratrol 16μM R03 exp147	-2.18
Centrinone 0.5μM R07 exp343	-2.17
Rapamycin 1μM R00 exp29	-2.16
Resminostat 0.5μM R07 exp393	-2.16
Salubrinal 20μM R07 exp399	-2.16
CB-839 10μM R05 exp224	-2.15
Taxol 0.002μM R01 exp54	-2.14
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.13
5-Azacytidine 2μM R07 exp330	-2.13
Benzoate 10000μM R08 exp455	-2.13
MS023 2μM R03 exp134	-2.11
IU1-47 25μM R04 exp182	-2.09
Parthenolide 2.5μM R05 exp238	-2.09
Campthothecin 0.001μM R06 exp270	-2.08
Daidzin 10μM R06 exp280	-2.08
UM131593 0.1μM R01 exp58	-2.08
Cerivastatin 0.15μM R05 exp226	-2.07
Thioridazine 5μM R08 exp530	-2.07
Hydroxyurea 100μM R07 exp329	-2.06
Ibrutinib 1μM R07 exp372	-2.06
SGC0946 7μM R03 exp151	-2.05
B02 10μM R08 exp453	-2.04
Epigallocatechin gallate 20μM R05 exp230	-2.04
SB743921 0.001μM R05 exp244	-2.04
All-trans-Retinoic-Acid 8μM R07 exp333	-2.03
A-395 10μM R05 exp218	-2.02
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.01
Dexamethasone 0.006μM R07 exp351	-2
Docetaxel 0.002μM R01 exp45	-1.99
Sucrose 20000μM R06 exp298	-1.99
TGF-beta1 44ng/ml R08 exp528	-1.99
Pyronaridine 1μM R06 exp295	-1.98
LLY-283 2.6μM R06 exp290	-1.95
Artemisinin 50μM R08 exp450	-1.94
KU-0063794 3.8μM R02 exp71	-1.92
Cabazitaxel 0.001μM R05 exp223	-1.89
CyclicAMP 200μM R08 exp475	-1.89
VE-822 0.04μM R06 exp300	-1.89
2-Methoxyestradiol 0.55μM R07 exp310	-1.87
GSK591 2.6μM R03 exp128	-1.87
Dihydrosphingosine 8μM R08 exp476	-1.86
Rifampicin 30μM R08 exp430	-1.86
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.85
Cannabidiol 13μM R08 exp465	-1.84
PF-06409577 20μM R07 exp389	-1.84
MS023 7μM R03 exp135	-1.82
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.8
RO-3306 3 to 4μM on day4 R04 exp165	-1.8
GW501516 25μM R06 exp285	-1.78
Aphidicolin 0.4μM R08 exp440	-1.77
Etoposide 0.1μM R05 exp198	-1.77
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.77
Thimerosal 0.85μM R08 exp529	-1.77
RS-1 10μM R08 exp519	-1.76
Nicotine 3000μM R08 exp510	-1.73
QNZ 0.01μM R08 exp439	-1.73
MSC2530818 10μM R07 exp379	-1.72
Olaparib 4μM R08 exp512	-1.72
S-trityl-L-cysteine 0.5μM R05 exp243	-1.72
Trametinib 10μM R02 exp83	-1.7
GSK2606414 1μM R05 exp236	-1.7
Ribavirin 10μM R01 exp52	-1.7

Gene	Correlation
GTF3C2	0.441
MED4	0.432
UXS1	0.425
TARDBP	0.424
FLI1	0.423
MED16	0.416
DPAGT1	0.413
RTCB	0.408
ZBTB11	0.406
KNTC1	0.403
EZH2	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9537
Expression level (log2 read counts): 9.35

Expression Distribution

beta-catenin-TCF7L2 complex
TFIIB-class transcription factor binding
beta-catenin-TCF complex
bHLH transcription factor binding
E-box binding
transcription initiation from RNA polymerase II promoter
protein C-terminus binding
protein-DNA complex assembly
transcription factor complex
DNA-templated transcription, initiation
nuclear chromatin
protein-DNA complex subunit organization
positive regulation of neuron differentiation
DNA-binding transcription activator activity, RNA polymerase II-specific
positive regulation of neurogenesis
transcription by RNA polymerase II
protein heterodimerization activity
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of nervous system development
positive regulation of cell development
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of neuron differentiation
DNA-binding transcription factor activity
regulation of neurogenesis
cellular protein-containing complex assembly
protein homodimerization activity
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
identical protein binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
positive regulation of developmental process
DNA binding
generation of neurons