Resminostat 0.5μM R07 exp393
Mechanism of Action
Inhibits HDAC 1, HDAC3, HDAC6
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Compound References
- PubChem Name: Resminostat (hydrochloride)
- Synonyms: RAS2410 hydrochloride; 4SC-201 hydrochloride
- CAS #: 1187075-34-8
- PubChem CID: 16662815
- IUPAC: (E)-3-[1-[4-[(dimethylamino)methyl]phenyl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide;hydrochloride
- INCHI Name: InChI=1S/C16H19N3O4S.ClH/c1-18(2)11-13-3-6-15(7-4-13)24(22,23)19-10-9-14(12-19)5-8-16(20)17-21;/h3-10,12,21H,11H2,1-2H3,(H,17,20);1H/b8-5+;
- INCHI Key: BVXPKDRKHXARHY-HAAWTFQLSA-N
- Molecular Weight: 385.9
- Canonical SMILES: CN(C)CC1=CC=C(C=C1)S(=O)(=O)N2C=CC(=C2)C=CC(=O)NO.Cl
- Isomeric SMILES: CN(C)CC1=CC=C(C=C1)S(=O)(=O)N2C=CC(=C2)/C=C/C(=O)NO.Cl
- Molecular Formula: C16H20ClN3O4S
Compound Supplier
- Supplier Name: Cayman Chemical
- Catalog #: 17553
- Lot #: 0469993-6
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C16H19N3O4S 350.1169; found 350.11655
Dose Response Curve
- Platform ID: Resminostat
- Min: -12.7317; Max: 99.4049
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.3190 |
| IC30 | 0.4071 |
| IC40 | 0.5085 |
| IC50 | 0.6321 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 500nM
- Days of incubation: 8
- Doublings: 6.4
- Numbers of reads: 20925235
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/1 | Scores |
Resminostat 0.5μM R07 exp393
Resminostat 0.5μM R07 exp393 vs Trichostatin-A 0.06μM R07 exp415
Asunaprenir 3μM R07 exp336 vs Resminostat 0.5μM R07 exp393
