RAD21L1

Entrez Summary: N/A
UniProt Summary: Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rad21 Rec8 N
Rad21 Rec8

nuclear meiotic cohesin complex
meiotic telomere tethering at nuclear periphery
meiotic attachment of telomere to nuclear envelope
chromosome attachment to the nuclear envelope
telomere tethering at nuclear periphery
meiotic cohesin complex
meiotic telomere clustering
seminiferous tubule development
chromosome localization to nuclear envelope involved in homologous chromosome segregation
lateral element
telomere localization
synaptonemal complex assembly
synaptonemal complex organization
synapsis
sister chromatid cohesion
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
establishment of chromosome localization
chromosome localization
meiotic chromosome segregation
double-strand break repair via homologous recombination
recombinational repair
meiosis I
meiosis I cell cycle process
chromosome
male gonad development
development of primary male sexual characteristics
sister chromatid segregation
meiotic nuclear division
male sex differentiation
meiotic cell cycle process
fertilization
double-strand break repair
gonad development
development of primary sexual characteristics
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
sex differentiation
chromosome segregation