RAD21L1 [The Human Chemical-Genetic Interaction Map Project]

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======= RAD21L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAD21L1
  * **<color #00a2e8>Official Name</color>**: RAD21 cohesin complex component like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=642636|642636]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4I0|Q9H4I0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAD21L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAD21L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619533|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad21 Rec8 N|
|Rad21 Rec8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear meiotic cohesin complex|
|meiotic telomere tethering at nuclear periphery|
|meiotic attachment of telomere to nuclear envelope|
|chromosome attachment to the nuclear envelope|
|telomere tethering at nuclear periphery|
|meiotic cohesin complex|
|meiotic telomere clustering|
|seminiferous tubule development|
|chromosome localization to nuclear envelope involved in homologous chromosome segregation|
|lateral element|
|telomere localization|
|synaptonemal complex assembly|
|synaptonemal complex organization|
|synapsis|
|sister chromatid cohesion|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|establishment of chromosome localization|
|chromosome localization|
|meiotic chromosome segregation|
|double-strand break repair via homologous recombination|
|recombinational repair|
|meiosis I|
|meiosis I cell cycle process|
|chromosome|
|male gonad development|
|development of primary male sexual characteristics|
|sister chromatid segregation|
|meiotic nuclear division|
|male sex differentiation|
|meiotic cell cycle process|
|fertilization|
|double-strand break repair|
|gonad development|
|development of primary sexual characteristics|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|sex differentiation|
|chromosome segregation|
|nuclear division|
|organelle fission|
|establishment of organelle localization|
|chromatin binding|
|reproductive structure development|
|reproductive system development|
|DNA repair|
|spermatogenesis|
|male gamete generation|
|organelle localization|
|developmental process involved in reproduction|
|gamete generation|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|cellular response to stress|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.95|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.76|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10727
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAD21L1 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>