ING5

Entrez Summary: N/A
UniProt Summary: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. {ECO:0000269|PubMed:12750254, ECO:0000269|PubMed:16387653}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.225μM R08 exp444	-2.7
Azithromycin 100μM R08 exp452	-2.2
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.08
THZ531 0.11μM R07 exp409	-1.94
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.86
Cannabidiol 20μM R08 exp466	-1.84
BI-D1870 3.15μM R02 exp66	1.75
UMK57 1μM R01 exp59	1.76
5-Fluorouracil 20μM R00 exp2	1.77
Genistein 15μM R07 exp360	1.77
Demecolcine 0.03μM R05 exp228	1.79
Bleomycin 5μM R08 exp459	1.8
Vincristine 0.0005μM R04 exp190	1.83
Vinblastine 0.002μM R01 exp60	1.88
Resminostat 0.5μM R07 exp393	1.93
Rotenone 20μM R00 exp34	1.97
Docetaxel 0.002μM R01 exp45	2.16
Tubastatin-A 2.5μM R07 exp417	2.19
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.23
Bortezomib 0.005μM R00 exp6	2.48
3-Bromopyruvate 7μM R04 exp175	2.56
UM131593 0.2μM R03 exp106	2.88

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ING
PHD

MOZ/MORF histone acetyltransferase complex
histone H3 acetylation
methylated histone binding
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
positive regulation of apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
protein acylation
DNA replication
negative regulation of growth
peptidyl-lysine modification
histone modification
covalent chromatin modification
chromatin binding
regulation of apoptotic signaling pathway
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of growth
negative regulation of cell population proliferation
positive regulation of cell death
chromatin organization
peptidyl-amino acid modification
chromosome organization
regulation of apoptotic process
positive regulation of transcription, DNA-templated
regulation of programmed cell death
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of signal transduction
regulation of cell death
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction